Super odor reveals odors associated with Alzheimer's, liver disease and cancer



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A "super perfumer" who detected her husband's Parkinson's disease a decade before the diagnosis revealed revealing odors associated with other illnesses.

Former nurse Joy Milne from Glasgow said she noticed that her 30-year-old husband had a different smell when he was still in his thirties, describing the smell as "a smell of wood. and musk ". He was diagnosed with Parkinson's disease 12 years later, in 1985.

Tests since then suggest that Joy's nose is so sensitive that it is able to capture the smell of sebum – the oil secreted by the skin – that we know to be produced by patients with Parkinson's.

In the morning of today, Joy, over the age of 60, explained that Parkinson 's disease was not the only one to clear a distinct scent.

She suggested that tuberculosis smelled brine, while the cancer had a "earthy" scent. Alzheimer's disease feels "sweet", but liver disease produces a "strong bile odor".

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Former nurse Joy Milne, of Glasgow, said that she had noticed that her husband felt them differently more than a decade before he was diagnosed with Parkinson's disease. Speaking this morning today (photo), she revealed the smells that she associates with other diseases

Former nurse Joy Milne, of Glasgow, said that she had noticed that her husband felt them differently more than a decade before he was diagnosed with Parkinson's disease. Speaking this morning today (photo), she revealed the smells that she associates with other diseases

Joy had already told how she had discovered her unique talent at the age of 21, when she had talked about the smell of liver cancer to a sister of the service while she was working as student nurse in a hospital.

The observation was rejected and she did not mention the idea until the diagnosis of Les.

Speaking at the beginning of her remarks, Joy said this morning: "I was able to find out from the beginning. It was sebum of the forehead, hair and nape, and it's a growing odor in people with Parkinson's disease.

She continued, "It all started with my husband. I noticed a different smell from him. He did not like perfumes or deodorants, he just had a nice smell of musk, but then I felt that wet and heavy musk, which was not nice.

Joy, in This Morning's photo, suggests that tuberculosis smells like brine, while cancer has an "earthy" scent. Alzheimer's disease feels "sweet", but liver disease produces a "strong bile odor"

Joy, in This Morning's photo, suggests that tuberculosis smells like brine, while cancer has an "earthy" scent. Alzheimer's disease feels "sweet", but liver disease produces a "strong bile odor"

"We went to our first meeting on Parkinson's disease. After I told him, "I think you should sit down." I told him, "These people smell like you."

& # 39; He had lost his sense of smell before I started to smell it. & # 39;

"You will not ask people how they feel. I did not know that it was so exacerbated. I realize it now.

Dr. Chris added, "Sebum is the oil of the skin and people with Parkinson's disease secrete a certain amount. So, you can detect that.

Joy's sense of smell has since been used to help scientists identify Parkinson's biomarkers that could lead to a new diagnostic test.

The grandmother's nose was also used during a visit to Tanzania, where she met people struggling with tuberculosis.

She continued: "I felt the first pad smell of brine and smell of wet cardboard."

Meanwhile, in California, she was "helping a friend" to comment on the potential odors associated with cancer.

Joy's late husband, Les (right), was diagnosed with Parkinson's disease in 1985, but 12 years earlier, Joy had noticed a change in her scent, which had alerted her about her illness.

Joy's late husband, Les (right), was diagnosed with Parkinson's disease in 1985, but 12 years earlier, Joy had noticed a change in her scent, which had alerted her about her illness.

How has Joy's nose helped scientists determine the causes of Parkinson's odor?

In a new study from the University of Manchester, the grandmother and former nurse managed to separate the affected and unaffected from the neurological condition based on the scent of oils wiped from their backs.

The researchers hope that their study will lead to a non-invasive test to diagnose Parkinson's disease at an early stage – doctors are currently forced to rely solely on symptoms.

The first study of its kind was led by Dr. Perdita Barran, Professor of Mass Spectrometry.

Dr. Barran conducted research several years ago, revealing that Ms. Milne could detect "the smell of Parkinson's" when sebum – the waxy oil that keeps skin hydrated – is collected in the back of the body. patient, but not when it comes from his armpits.

In the most recent study, researchers collected sebum from the upper back of 43 patients with Parkinson's disease and 21 controls.

Excessive sebum production is a symptom of Parkinson's disease, with people with higher levels of α-synuclein protein in their skin.

Odor compounds were extracted from these sebum samples and heated to "encourage the production of volatile substances".

Ms. Milne then proceeds to sniff the samples via an "odor port".

The results published in the ACS Central Science review revealed that the Super Smeller had detected a characteristic musky odor in people with Parkinson's disease.

In the UK, about one in 350 adults is diagnosed with Parkinson's disease, according to Parkinson & # 39; s UK.

And according to statistics from the Parkinson Foundation, more than 10 million people live with the disease in the United States.

"Dogs have been diagnosing cancer for years," she said. "It really smells like smell. It's an earthy smell. I linked it to something, but I can not discuss it. & # 39;

Joy went on to say that Alzheimer's disease had a "sweet" smell and was pleasant at first, but quickly turned into a "nasty" scent.

She added, "It's a vanilla smell. It starts to smell good and then it gets pretty mean. A wet and musky neurological odor.

In the meantime, "liver disease, you have that very strong smell of bile," she noted. Dr. Chris nodded, "It smells almost faecal."

Presenters Phillip Schofield and Holly Willoughby were impressed by Joy's skill, but she insisted that it was a huge "responsibility". She also added that it could not be used for diagnosis.

Parkinson's disease is incurable and Phillip asked his guests if "it was good" to know that someone was suffering from the disease in advance.

Dr. Chris replied, "You will not heal. But if you are aware that your body behaves in this way, you can delay the deterioration and improve your quality of life.

Joy said people with Parkinson's disease smelled of sebum, which Dr. Chris confirmed by revealing that sufferers had a lot more sweat.

Presenters Phillip Schofield and Holly Willoughby were impressed by Joy's talent, but she insisted that it was a huge "responsibility". In the photo, the trio with Dr. Chris this morning today

Presenters Phillip Schofield and Holly Willoughby were impressed by Joy's talent, but she insisted that it was a huge "responsibility". In the photo, the trio with Dr. Chris this morning today

"HE STARTED WITH BAD ODOR"

Mrs. Milne noticed a "kind of musky and fat smell" at her husband's house (photo). He was diagnosed a decade later and died in 2015 at the age of 65.

Mrs. Milne noticed a "kind of musky and fat smell" at her husband's house (photo). He was diagnosed a decade later and died in 2015 at the age of 65.

Joy and Les Milne were childhood lovers who started dating together at only 16 years old.

When they reached the mid-thirties, Ms. Milne – then a nurse – noticed a change in her husband's smell.

"He started to feel uncomfortable for me and although we've always been a loving couple, I've always been aware of it," she said.

Mrs. Milne described it as "a musky and oily smell" and would urge her husband to shower and brush more.

A decade later, at the age of 45, Mr. Milne was finally diagnosed as suffering from Parkinson's disease after battling tremors, as well as fatigue and impotence.

About the time of his diagnosis, Mr. Milne's personality changed: the doctor, who was once a gentle man, struck his wife twice, inflicting bruising on his face.

"While this was going on, his eyes seemed empty, as he had no idea what he was doing," Ms. Milne said.

Over the next 20 years, the former swimmer and water polo player became dependent on a walking cadre.

He was even forced to retire from his consulting anesthetist activity because of his tremors and his reduced concentration.

The couple (photo on the day of their marriage) started dating at just 16 years old

The couple (photo on the day of their marriage) started dating at just 16 years old

In 2005, the couple returned from Cheshire to her hometown of Perth, Scotland, where Ms. Milne linked Parkinson's disease with her husband's smell by accompanying her to a group of support.

"After we left, I told Les:" People with Parkinson's disease in this room were feeling the same as you, "Ms. Milne said.

In 2010, she contacted Tilo Kunath, a researcher in the field of Parkinson's disease, from the University of Edinburgh, who put her skills to the test a year later.

After asking 12 volunteers to wear a t-shirt for 24 hours, Ms. Milne correctly identified the pathological status of 11 of them – the only one she cheated was diagnosed with. Next year.

Shortly after, Mr. Milne lost his fight against Parkinson's disease in 2015, at the age of 65.

Ms. Milne has since been keen on her husband's willingness to participate in the research on the smell of Parkinson's disease.

But Parkinson's is not the only illness that Mrs. Milne can detect.

As a nursing student, she says she spotted people with gallstones before they were diagnosed.

And during her midwifery training, she could tell if a woman was smoking or had diabetes because of the smell of her placenta.

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