[ad_1]
Press release
Wednesday, May 22, 2019
New findings from a study by researchers at the National Cancer Institute (NCI), belonging to the National Institutes of Health, show that the US incidence rate of aggressive cancer subtypes of Uterus has increased rapidly among women aged 30 to 79 from 2000 to 2015. The findings also reveal racial disparities, including a higher incidence of these aggressive subtypes and poorer survival – whatever the subtype and stage of cancer – among non-Hispanic black women compared to women from other racial / ethnic groups.
The study, published May 22, 2019 in the Journal of Clinical Oncology, used population data from the NCI's Surveillance, Epidemiology and End-Use Database (SEER) to assess trends in uterine cancer incidence rates among women in general, by race and ethnicity, region and histological subtype (subtypes differentiated by how tumor tissue appears under the microscope) . The authors corrected the prevalence of hysterectomy using data from the Behavioral Risk Factor Surveillance System to estimate uterine cancer incidence rates because women undergoing hysterectomy no longer risked developing the disease. Many previous studies on the incidence of uterine cancer did not include such a correction.
"The incidence rates of uterine cancer have increased and racial differences have been reported in incidence and survival rates, with disparities observed for non-Hispanic black women," he said. said Megan Clarke, Ph.D., lead author of the study. and Postdoctoral Fellow at NCI's Division of Epidemiology and Cancer Genetics. "But few recent studies have corrected hysterectomy, which can vary by race, ethnicity and region. The correction for the prevalence of hysterectomy gives us a more accurate picture of trends in overall incidence, as well as rates by race and ethnicity. "
The study found that, in all women, hysterectomy-corrected uterine cancer incidence rates had increased by approximately 1% per year between 2003 and 2015. Rates incidence increased more rapidly among women from other racial / ethnic groups than among white women. The incidence rates of uterine cancer among black women surpassed those of white women in 2007 and were consistently higher from 2011 to 2015.
The researchers also examined separately the subtypes of endometrioid and non-endometrioid uterine cancers. Compared with non-endometrioid subtypes, endometrioid subtypes are more common, usually have better prognoses and better survival rates, and have a stronger association with hormonal risk factors and the same. obesity. A new approach to account for missing histological information was used to improve subtype-specific incidence estimates.
Rates of incidence of endometrioid subtypes were stable in non-Hispanic white women during the study period and increased in women of other racial / ethnic groups. In contrast, the incidence rates of non-endometrioid aggressive subtypes increased dramatically over time in all racial / ethnic groups (overall increase of 2.9% per year from 2000 to 2015). Researchers also observed significantly higher rates of aggressive non-endometrioid subtypes in black women (25.9 per 100,000 women over the study period) compared to white women (11.4), Hispanic women (10.1) and Asian / Pacific Island women (7.5).
The researchers also found that the 5-year relative survival rate was lower in all women with non-endometrioid subtypes compared with women with endometrioid subtypes and that black women had lower rates of survival, at each stage of the diagnosis or histological subtype.
"All of these trends – uterine cancer rates in black women exceeding those of white women, higher incidence rates of non-endometrioid subtypes in black women and more survival rates Weak black women for all cancers of the uterus – are very worrisome, "said Dr. Clarke said. "We need to continue research to better understand these racial differences and disparities, to help us better anticipate risks and work toward prevention."
One of the key messages of this study is that these non-endometrioid aggressive cancers are increasing in all women, said Dr. Clarke. She explained that since these cancers are much rarer than the endometrioid subtypes, less is known about them. Important next steps include conducting research on the underlying causes of these subtypes to improve risk prediction and early detection of all uterine cancers.
The increasing incidence of non-endometrioid subtypes is probably not explained by the increasing prevalence of obesity and changes in the use of hormone replacement therapy, these factors being more closely associated with endometrioid subtypes, whose remained more stable over the Clarke period explained.
"If the rising incidence rate was primarily related to obesity, we would see no stable trends for endometrioid subtypes in white women," she said. "Obesity is the strongest risk factor associated with endometrioid subtypes. However, our study suggests that there are other factors that increase the incidence of uterine cancer, which justifies additional research.
About the National Cancer Institute (NCI): NCI leads the National Cancer Control Program and NIH's efforts to dramatically reduce the prevalence of cancer and improve the lives of cancer patients and their families through research on prevention and biology cancer, the development of new interventions, the training and mentoring of new researchers. For more information on cancer, visit the NCI website at cancer.gov or call the NCI Contact Center, Cancer Information Service, at 1-800-4-CANCER (1 -800-422-6237).
About the National Institutes of Health (NIH):
The NIH, the country's medical research agency, has 27 institutes and centers and is part of the US Department of Health and Human Services. NIH is the lead federal agency that leads and supports basic, clinical and translational medical research. She studies causes, treatments and cures for common and rare diseases. For more information on NIH and its programs, visit www.nih.gov.
NIH … transforming discovery into health®
[ad_2]
Source link