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WASHINGTON, July 20 (Xinhua) – A study published Friday in the journal Cell Death & Disease showed that mice developed with wrinkled skin and visible hair loss could be restored by extinguishing a gene, giving an index of potential
When a mutation leading to mitochondrial dysfunction was restored, the mice found a smooth skin and a thick fur, indistinguishable from a healthy mouse of the same age, discovered researchers of the 39, University of Alabama at Birmingham (UAB).
In humans, a decline in mitochondrial function is observed during aging, and mitochondrial dysfunction can lead to age-related diseases
"This mouse model should offer an unprecedented opportunity for development of preventive and therapeutic development strategies, mitochondrial functions for the treatment of cutaneous and capillary pathology badociated with aging and other human diseases in which mitochondrial dysfunction plays an important role "d Keshav Singh, professor of genetics at the UAB School of Medicine who led the study.
The mutation in the murine model is induced when doxycycline antibiotic is added to food or drinking water, resulting in depletion of mitochondrial DNA. the enzyme to replicate the DNA becomes inactive, according to the study.
In four weeks, the mice showed gray hair, reduced hair density, hair loss, sluggishness and lethargy.
eight weeks after induction of the mutation, and females exhibited more severe skin wrinkles than males.
According to the study, the skin of mutated mice induces an increased number of cutaneous cells, abnormal thickening of the outer layer, dysfunctional hair follicles
These are similar to extrinsic aging of the skin at home. l & # 39; man. The effect of external factors include skin wrinkles that develop from excessive sun or long-term smoking.
Mice with exhausted mitochondrial DNA also showed changed expression of four markers badociated with aging in cells, similar to intrinsic aging However, this hair loss and this wrinkled skin were inverted approximately a month later after stopping the doxycycline, allowing the restoration of depleted mitochondrial DNA.
They found that mutation reversal restored mitochondrial function. like the pathology of the skin and hair. This showed that mitochondria were reversible regulators of skin aging and hair loss.
Mitochondria in cells, known as the central cells, produce 90 percent of the chemical energy that cells need to survive.
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