Antipsychotics for the prevention of delirium in adults | Annals of Internal Medicine



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Johns Hopkins University School of Medicine, Baltimore, Maryland (E.S.O., D.M.N., R.N., K.A.R., K.J.N.)

Bloomberg School of Public Health Johns Hopkins, Baltimore, Maryland (L.M.W., A.Z.)

Warning: The project was funded by the HHSA290201500006I / HHSA29032008T contract from AHRQ, the US Department of Health and Human Services (HHS). The authors of this manuscript are responsible for its content. The statements contained in the manuscript do not necessarily reflect the official views of AHRQ or HHS nor imply their endorsement.

Recognition: The authors thank Carrie Price, MLS, for reviewing our literature search by our peers. They also acknowledge the contributions of Sumana Vasishta, MBBS; Mounica Koneru, MBBS; Jeanette Edelstein, MA; Sriharsha Singu, MBBS; Amulya Balagani, MBBS; Louay H. Aldabain, MD, Narjes Akhlaghi, MD; Mary Zulty, DO; Sanjay Singh, MD; and Matthew Picchiello, BA.

Financial aid: By the AHRQ (contract 290-2015-00006I-2).

Disclosures: Dr. Needham reports a contract from the AHRQ while conducting the study. Dr. Nikooie reports an AHRQ contract while conducting the study. Dr. Neufeld reports a contract from the AHRQ during the conduct of the study, Merck's personal fees and Hitachi grants outside of the submitted work. Ms. Wilson reports the AHRQ contract HHSA290201500006I / HHSA29032008T during the course of the study. Mr. Zhang reports a contract from the AHRQ while conducting the study. Dr. Robinson reports a contract from the AHRQ while conducting the study. Dr. Neufeld reports a contract from the AHRQ during the conduct of the study, Merck's personal fees and Hitachi grants outside of the submitted work. Drs. Neufeld and Needham were members of the Society of Critical Care Medicine's Clinical Practice Guidelines panel for the prevention and management of pain, restlessness / sedation, delirium, immobility and sleep disorders. in adult patients of the ICU and the American Geriatrics Society. Postoperative delirium in the elderly. The first author and none of the other authors have affiliations or financial implications in conflict with the information presented in this report. The unnamed authors here have revealed no conflict of interest. Disclosures can also be found at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-1859.

Disclosures of the editors: Christine Laine, MD, MPH, editor-in-chief, says his wife holds stock / asset purchase options with targeted diagnoses and therapies. Darren B. Taichman, MD, PhD, editor, says that he has no financial relationship and no interest in disclosing. Cynthia D. Mulrow, MD, MSc, Senior Editor, says she has no relationship or interest in disclosing. Jaya K. Rao, MD, MHS, Associate Editor, says she has stock / stock options at Eli Lilly and Pfizer. Catharine B. Stack, PhD, MS, associate chief statistics editor, says she owns shares in Pfizer, Johnson & Johnson and Colgate-Palmolive. Christina C. Wee, MD, MPH, Associate Editor, reports a job at Beth Israel Deaconess Medical Center. Sankey V. Williams, MD, deputy editor, says that he has no financial relationship and no interest in disclosing. Yu-Xiao Yang, MD, MSCE, deputy editor, says that he has no financial relationship nor any interest in disclosing.

Repeatable Research Statement:Study protocol: Available at www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018109552. Statistical code and dataset: Available from Ms. Wilson (e-mail [email protected]); the abstract data to be fully examined is published in the Systematic Review data repository (https://srdr.ahrq.gov/).

Corresponding author: Karin J. Neufeld, MD, MPH, Department of Psychiatry, Johns Hopkins Bayview Medical Center, A4 Center, Suite 457, 4940 Eastern Avenue, Baltimore, MD 21224. Email, [email protected].

Address of the current author: Dr. Oh: Division of Geriatric Medicine and Gerontology, Faculty of Medicine, Johns Hopkins University, Mason F. Lord Center Tower, 5200 Eastern Avenue, 7th Floor, Baltimore, MD 21224.

Dr. Robinson: Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 8068, Baltimore, MD 21287.

Drs. Needham and Nikooie: Division of Critical Care and Pulmonary Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Fifth Floor, Baltimore, MD 21287.

Ms. Wilson and Mr. Zhang: Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, 6th Floor, Baltimore, MD 21205.

Dr. Neufeld: Department of Psychiatry, Johns Hopkins Bayview Medical Center, A4 Center, Suite 457, 4940 Eastern Avenue, Baltimore, MD 21224.

Author contributions: Design and Design: E. S. Oh, D. M. Needham, R. Nikooie, L. M. Wilson, A. Zhang, K. A. Robinson, K. J. Neufeld.

Data Analysis and Interpretation: E. S. Oh, D. M. Needham, R. Nikooie, L. M. Wilson, A. Zhang, K. A. Robinson, K. J. Neufeld.

Article Writing: E.S. Oh, R. Nikooie, A. Zhang, K.A. Robinson, K.J. Neufeld.

Critical review of the article for important intellectual content: E.S. Oh, D.M. Needham, R. Nikooie, L.M. Wilson, A. Zhang, K.A. Robinson, K.J. Neufeld.

Final approval of the article: E. S. Oh, D. M. Needham, R. Nikooie, L. M. Wilson, A. Zhang, K. A. Robinson, K. J. Neufeld.

Supply of study materials or patients: L.M. Wilson, A. Zhang.

Statistical Expertise: A. Zhang.

Obtaining funding: D.M. Needham, A. Zhang, K. A. Robinson, K.J. Neufeld.

Administrative, Technical or Logistical Assistance: D.M. Needham, L.M. Wilson, A. Zhang, K. A. Robinson, K.J. Neufeld.

Collecting and Assembling Data: E.S. Oh, R. Nikooie, L.M. Wilson, A. Zhang, K.A. Robinson, K.J. Neufeld.

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