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However, when the researchers added (S) -α-fluoromethyl tyrosine (AFMT), which has a strong structural similarity with tyrosine, it prevented the degradation of L-dopa by E. faecalis. Apparently, the human dopa decarboxylase and the bacterial tyrosine decarboxylase differ so much from one another as that adapted to the human enzyme medicine Carbidopa does not work in the bacteria, the researchers concluded. An animal experiment confirmed their theory: in mice colonized with E. faecalis, concomitant administration of AFMT, L-dopa and carbidopa increased blood levels of L-dopa.
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