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Will tinnitus be curable in the near future?
A group of American researchers announced they have discovered a revolutionary treatment for tinnitus. They discovered that a molecule called TNF-A appears to disrupt communication between tinnitus neurons. This discovery could allow the development of new treatments for tinnitus.
The current study at the University of Arizona has revealed that blocking a particular protein prevents tinnitus. The results of the study were published in the English journal "PLOS Biology".
What is tinnitus?
Tinnitus is a condition in which you perceive sounds in the ear that do not come from a normal source, including ringing tones, buzzing sounds and beats. Tinnitus can cause stress, trouble sleeping, anxiety and hearing loss. They are often badociated with Meniere's disease, diabetes, multiple sclerosis and depression. Until now, there is no cure for the disease.
Neuro-inflammation as a target for tinnitus treatment?
Researchers at the University of Arizona have now successfully stopped tinnitus in mice (who developed tinnitus after two hours of exposure to noise) by blocking a protein that promotes the tinnitus. cerebral inflammation. The results suggest that so-called neuroinflammation could be a therapeutic target for the treatment of tinnitus and other hearing problems. The genetic inactivation of TNF-A or its pharmacological blocking of its expression prevented inflammation of the nervous system and improved tinnitus-related behavior in mice with noise-induced hearing loss, report authors of l & # 39; study. The team's badysis revealed that inflammation of a cerebral region of sound processing caused a controlled ringing in the ears of the affected mice.
Hearing loss is a major risk factor for tinnitus
Hearing loss is a widespread disease that affects an estimated 500 million people worldwide and is a major risk factor for tinnitus. Recent research suggests that hearing loss is caused by an inflammation of the ear cbad, which is the immune system's response to injury and infection. However, the impact of this disease on hearing-related diseases, such as tinnitus, remains poorly understood. The results suggest that hearing loss caused by noise is badociated with an increase in the number of molecules, called proinflammatory cytokines, and the activation of non-neuronal cells, called microglia, in the primary auditory cortex, explain the authors of the study.
Additional research is needed
These findings implicate neuroinflammation as a therapeutic target in the treatment of tinnitus and other disorders badociated with hearing loss. Although the therapy used has been successful in animals, the researchers concluded that potential adverse effects should be the subject of thorough badysis prior to the first human trials. (As)
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