Bad olfaction and mortality in the elderly | Annals of Internal Medicine



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Karolinska Institutet, Stockholm, Sweden, and Michigan State University State University of Human Medicine, East Lansing, Michigan (B.L.)

Michigan State University Medical School, East Lansing, Michigan (Z.L., H.C.)

University of Chicago, Chicago, Illinois (J.M.P.)

National Institute on Aging National Institutes of Health, Bethesda, Maryland (E.J.S., T.B.H.)

California Pacific Medical Center Research Institute, San Francisco, California (G.J.T.)

Karolinska Institutet, Stockholm, Sweden (K.W., F.F.)

Warning: Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily approved by the National Institutes of Health or the Ministry of Defense.

Recognition: The authors thank the Drs. Arvid Sjölander and Johan Steen for their valuable contributions and discussions in statistical analysis.

Financial aid: Through the intramural research program of the National Institutes of Health (National Institute of Aging) and by contracts N01AG62101, N01AG62103 and N01AG62106 of the National Institute of Aging. Dr. Fang is supported by a Senior Investigator Award and a Strategic Research Award in Epidemiology from the Karolinska Institutet. Dr. Chen is receiving support from Michigan State University's GE100455 start-up fund, the Parkinson's Foundation's PF-IMP-1825 grant, and the W81XWH-17-1-0536 award from the Assistant Secretary's office in Toronto. Defense for Health Affairs Parkinson's Research Program.

Disclosures: Dr. Pinto reports grants from the National Institute of Aging and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health while conducting Stallergenes' study and personal fees. and Optinosis outside of the submitted work. The unnamed authors here have revealed no conflict of interest. Disclosures can also be found at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M18-0775.

Disclosures of the editors: Christine Laine, MD, MPH, editor-in-chief, says his wife holds stock / asset purchase options with targeted diagnoses and therapies. Darren B. Taichman, MD, PhD, editor, says that he has no financial relationship and no interest in disclosing. Cynthia D. Mulrow, MD, MSc, Senior Editor, says she has no relationship or interest in disclosing. Jaya K. Rao, MD, MHS, Associate Editor, says she has stock / stock options at Eli Lilly and Pfizer. Catharine B. Stack, PhD, MS, associate chief statistics editor, says she owns shares in Pfizer, Johnson & Johnson and Colgate-Palmolive. Christina C. Wee, MD, MPH, Associate Editor, reports a job at Beth Israel Deaconess Medical Center. Sankey V. Williams, MD, deputy editor, says that he has no financial relationship and no interest in disclosing. Yu-Xiao Yang, MD, MSCE, deputy editor, says that he has no financial relationship nor any interest in disclosing.

Repeatable Research Statement:Study protocol and statistical code: See the supplement. Dataset: Unavailable.

Corresponding author: Honglei Chen, MD, PhD, Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, 909 Wilson Road, East Lansing, MI 48824; e-mail, [email protected].

Address of the current author: Drs. Liu, Wirdefeldt and Fang: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, 171 65 Solna, Stockholm, Sweden.

Dr. Luo: Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, 909 Wilson Road, West Fee Hall, Room B601, East Lansing, MI 48824.

Dr. Pinto: Department of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Chicago in Medicine and Biological Sciences, 5841 South Maryland Avenue, Chicago, IL 60637.

Drs. Shiroma and Harris: Laboratory for Epidemiology and Population Sciences, Intramural Research Program of the National Institutes of Health, National Institute of Aging, Building 31, Room 5C27, 31 Center Drive, MSC 2292, Bethesda , MD 20892.

Dr. Tranah: California Pacific Medical Center Research Institute, Box 0560, 550 16th Street, 2nd Floor, San Francisco, CA 94159.

Dr. Chen: Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, 909 Wilson Road, West Fee Hall, Room B645, East Lansing, MI 48824.

Author contributions: Design and Design: B. Liu, Z. Luo, F. Fang, H. Chen.

Analysis and Interpretation of Data: B. Liu, Z. Luo, J. M. Pinto, E. J. Shiroma, G. J. Tranah, F. Fang, T. B. Harris, H. Chen.

Article Writing: B. Liu, Z. Luo, H. Chen.

Critical review of the article for important intellectual content: B. Liu, Z. Luo, J. M. Pinto, E. J. Shiroma, G. J. Tranah, K. Wirdefeldt, F. Fang, T. B. Harris, H. Chen.

Final approval of the article: B. Liu, Z. Luo, J. M. Pinto, E. J. Shiroma, G. J. Tranah, K. Wirdefeldt, F. Fang, T. B. Harris, H. Chen.

Supply of study materials or patients: T.B. Harris.

Statistical Expertise: B. Liu, Z. Luo, F. Fang, H. Chen.

Obtaining funding: T.B. Harris, H. Chen.

Administrative, Technical or Logistical Assistance: B. Liu, E.J. Shiroma, K. Wirdefeldt, T. B. Harris, H. Chen.

Collection and assembly of data: B. Liu, H. Chen, T. B. Harris.

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