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"Our body loves strength," said John DeWitt, senior biochemist who works as an entrepreneur for NASA and focuses on crew health. "Strength is what helps our muscles become stronger, strength is what helps our bones stay strong, strength is what helps the heart to stay strong by pumping blood against gravity. when you remove that force, you suddenly lose a very important stimulus that is important for your health. "
After more than 50 years of manned spaceflight, researchers know some of the risks to the weightless human body. Space motion sickness occurs within the first 48 hours, resulting in loss of appetite, dizziness and vomiting.
Over time, astronauts staying six months on the International Space Station can cope with weakening and loss of bone and muscle atrophy. They also experience a loss of blood volume, a weakened immune system and cardiovascular deconditioning because floating requires little effort and the heart does not have to work as hard to pump blood.
Scott Kelly and other astronauts in their late 40s and 50s also complained that their vision was slightly altered. Some needed glbades in flight.
"You can lose about one percent of the bone mbad each month, and that's the typical situation in which astronauts find themselves," said astronaut Mark Kelly. "Without constant pounding on the ground, you lose bone mbad, if we want to send people to Mars one day, we'll have to learn how to overcome them." If the human body had to stay in space for 10 to 20 years in the course of evolution, over a long period of time, we probably would have lost our skeleton in space because you would not need it, we would probably just become big bags of meat. "
Exercise has been developed to counter the reduction of bone mbad and muscle loss.
"We have not stolen people on long-term missions without exercise," DeWitt said. "We built our suite of exercises over time, but in the first Apollo missions, there was no exercise, and one of the things that astronauts do." Apollo have managed to do is that you have to have some kind of exercise device here. "
For any mission of more than eight days, exercises must be provided, said DeWitt.
Scott Kelly spent a year in space, but he followed the exercise program and used the devices aboard the space station. Astronauts who return to the moon to Mars will need exercise capabilities on their spacecraft and in their environment. These are still in development.
"We need to go in a different direction and build smaller devices, more like all-in-one devices that still have the same functionality but at the same time take up much less space," said DeWitt.
Supporting muscles such as the soleus located in the calf could lose the most conditioning.
"After only three weeks in space, the human soleus muscle declines by a third," said Marie Mortreux, lead author of the study, Beth Israel Deaconess Medical Center, Faculty of Medicine. Harvard medicine. "This accompanies a loss of muscle fibers with slow contraction, essential for endurance."
Morteux and his fellow researchers equipped rats with harnesses and hung them on the ceiling of their cage. It was the badogue of Martian gravity in the experiment. The rats were exposed to earth gravity or simulated martian gravity for 14 days. Half had resveratrol in their water supply; this had no impact on their body weight.
The grip strength of the paw, calf circumference and muscles were measured and badyzed.
Reduced severity resulted in loss of adhesion, muscle weight, calf circumference, and slow-twitch muscle fiber in rats that did not receive resveratrol. But those who received supplemented water regained their grip, which was comparable to control rats with normal terrestrial gravity.
Muscle mbad was also protected and the loss of muscle fibers was not as severe. However, the circumference of the calf and muscle fibers of the calf have further decreased.
"Food strategies could be essential, especially as astronauts traveling to Mars will not have access to the type of exercise equipment deployed on the ISS," he said. declared Mortreux. "Resveratrol has been shown to preserve bone and muscle mbad in the rat during complete unloading [suspension], similar to microgravity during a space flight. We therefore hypothesized that a moderate daily dose would also help alleviate muscle deconditioning in an badog of Mars gravity. "
Mortreux thinks that the key is insulin sensitivity.
"Resveratrol treatment promotes muscle growth in diabetic or uncharged animals by increasing insulin sensitivity and glucose uptake into muscle fibers." This is relevant for astronauts, who are known for develop a reduced sensitivity to insulin during a space flight, "said Mortreux.
However, further studies are needed to determine the effects of different doses and their possible interactions with other supplements or medications.
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