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As the supplier of choice for scientists working in the field of bispecific antibodies worldwide, Creative Biolabs is dedicated all the time to collecting hot therapeutic targets and providing a variety of custom anti-bispecific antibody (BsAb) products.
New York, United States – October 23, 2018 – As the supplier of choice for scientists working in the field of bispecific antibodies worldwide, Creative Biolabs is dedicated to collecting targeted therapeutic targets and providing a variety of anti-bispecific antibody products all the time. (BsAb) custom.
Based on advanced strategies, different BsAb product formats can be developed to adapt valence, structure, half-life and biodistribution. etc.., including Tandem Fab, CrossMab, Tandem scFv, IgG-scFv, Diabody, IgG-IgG, Triple Body, Fab-IgG, TandAb, Single Chain Diabody, Single Body Three-Chain, corresponding to the desired profile of the target product
Tandem Fab, a clbad of Fab-based bispecific antibody fragments, comprises two Fabs targeting different epitopes. With higher thermal stability than the corresponding scFv, Fab is typically expressed as a 3-chain construct and has a His tag for affinity purification. The two regions Fd are connected by a flexible linker. Tandem Fab is bispecific and monovalent for each antigenic specificity (1 + 1 antigen binding valence).
CrossMab is a type of bispecific antibody type IgG that remains the general structure and size of a conventional IgG. In CrossMAb, KIH (Knobs-into-Holes) technology is used to enable heavy chain heterodimerization. Coupling errors in light chains are overcome by crosses of antibody domains, complete Fab domains, simply variable domains or constant domains. Crossover can retain the antigen binding ability of the parental antibody. In general, the CrossMab in question is a bispecific bivalent molecule, a 1 + 1 antigen binding valency, with biophysical properties similar to those of IgG. Multivalent and bispecific molecules can be generated using crossMab versatile technology.
Equipped with the latest technologies and state-of-the-art platforms, Creative Biolabs is able to offer a wide range of custom-tailored bispecific antibodies that cover all your needs. In addition, Creative Biolabs also offers custom design services for BsAb for scientific research or clinical practice early in the development of BsAb.
About Creative Biolabs
Creative Biolabs was created in 2004 by scientists dedicated to the fight against cancer. Over the past 10 years, Creative Biolabs has become a recognized world leader in discovery, engineering, production and antibody badysis (ABr). Standing on the shoulders of a giant, the Bispecific Antibody Team (BsAb) is a group of experienced scientists committed to providing high quality services to customers around the world. Now, with state-of-the-art platforms and methods (quadroma development, chemical conjugation and genetic engineering), a comprehensive list of bispecific antibody-based products is available for both academic and industrial customers.
Media contact
Company Name: Creative Biolabs
Contact: Bella Smith
E-mail: Send an email
Phone: 1-631-619-7922
Address:45-1 Ramsey Road
City: Shirley
State: New York
Country: United States
Website: https://www.creative-biolabs.com/bsab/
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