Prolonged ingestion of pesticides creates metabolic changes in mice

Prolonged pesticide use causes metabolic changes in mice as it makes males larger and causes liver disturbances and a change in microbiotic activity in females, a study published today. .

The experience of the National Institute of Research and Analysis of France (INRA) and the National Institute of Health and Medical Research (INSERM) have incorporated into the rodents diet a "badtail of pesticides" at a daily dose similar to that acceptable to humans

. ] After one year of exposure, equivalent to 30 years in the case of humans, it was observed that male mice had doubled their weight compared to others who had received a normal diet.

also diabetes and an accumulation of fats in the liver, while in females there were liver disturbances and changes in microbiotic activity.

He gave, in the French town of Toulouse (south) and published in the journal Environmental Health Perspectives, given the mice a badtail of six pesticides used to treat French apple trees and which were also found in the apples of the European Union. 19659002] Unlike other research, with a single high-dose pesticide, or combining other risk factors, such as a high-fat diet, this one has opted for this combination of several, says Laurence. Payrastre, Biologist, Participant at

Previous epidemiological studies had shown that biofeeding offered a lower risk of developing metabolic changes, and the findings of this research provide arguments to this theory, although it's about testing with mice and not with humans. 19659002] Payrastre pointed out that the effects detected in mice are less related to the amount of pesticides taken in food or water, but "to the prolongation of this intake over time."

Differences between males and females may be due to the protection offered by estrogen in the latter and to a different detoxification capacity (process of cleaning toxins in the body).

Experts now want to delve into the found differences and conclusions to identify the "molecular determinants" that their origin and if there would be a critical period of exposure to these compounds, such as pregnancy or lactation.