[ad_1]
Eliminating bacteria would be a "Trojan horse"
More and more bacteria become resistant to antibiotics, making some infections very difficult to treat.
Now, according to the results of a randomized Phase 2 trial, published in "The Lancet Infectious Diseases" and reiterating "ABC," a new antibiotic has proven to be as effective as the antibiotic standard for the treatment of complicated urinary tract infections caused by several Gram bacteria. negative drug-resistant.
The results show that the patients treated with the siderophore, cefiderocol, had a higher and more sustained level of pathogen eradication and clinical results similar to those treated with the standard of
Cefiderocol is innovative in its approach to overcome the three main mechanisms of biotic resistance used by Gram-negative bacteria: two external membranes that prevent the penetration of antibiotics, the porin channels that can adapt and modify to block the entry of antibiotics and outflow.
"The Cefiderocol acts like a Troy horse," says Simon Portsmouth, Shionogi Ing, USA, who led the research.
"The drug uses a new cell entry mechanism that exploits the bacteria's iron need to survive.On an acute infection, one of our innate immune responses is to create an iron-poor environment. In response, the bacteria increase their iron intake. "
As they explain, the cefiderocol binds to the iron channels and is transported through the extra outer membrane by the bacterium's transport system, which constitutes it. 19659003] New antibiotics are urgently needed, as the number of antibiotic-resistant infections has almost doubled since 2002.
According to some studies, by 2050, 10 million people will die each year. Resistant infections. medication.
New drugs
Experts believe that it is necessary to develop antibiotics that attack the bacteria in a completely new way. Last month, at IDWeek 2018, five promising antibiotics were presented for the treatment of resistant organism infections.
[ad_2]
Source link
