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A team of scientists from the American University of Tufts has succeeded in partially regenerating the amputated frog legs through progesterone treatment using a portable bioreactor attached to the wound site, published by the journal Cell Reports. [19659002] The results of this research can serve as a model for new cell stimulation therapies and allow advances in the treatment of amputation lesions in humans.
Some species of the animal world such as lizards or crabs can regenerate by themselves, but this does not occur in the case of the African nail frog, known under the scientific name Xenopus laevis and examined in the literature. framework of this study.
This type of water frog is able to regenerate itself in the early stages of its life but loses this ability in adulthood.
The researchers divided the frogs into three groups for their experiment and all sewed the portable bioreactor just to the location of the wound left by the amputation.
Only frogs from one of the groups. received progesterone by the bioreactor for 24 hours and researchers observed, for nine months, a partial regeneration of their unobserved ends in the other two groups.
"A very brief application of the bioreactor and its payload (progesterone) resulted in months of growth and tissue structures," explained Michael Levin, one of the study's authors and biologist at the Allen Discovery Center of Tufts University, Mbadachusetts (USA).
Frogs treated with progesterone had partially regenerated legs with bone, innervation and vascularization and could swim put into the water as if they had not been amputated.
Progesterone is a bad hormone known for its functions in the onset and development of pregnancy, but it has also been proven that it promotes the repair of nerves, blood vessels and bone tissue .
"We looked at progesterone because it looked promising repair and regeneration of the nerves, it also modulates the immune response to promote healing and triggers the regrowth of blood vessels and bones," said neuroscientist Celia Herrero-Rincón, author of the study.
The next step for researchers is to conduct a similar study in mammals. and try to get more evidence that the drug-device combination may constitute a new model for testing therapeutic badtails to induce the regeneration of non-regenerative species.
Worldwide, millions of people live with a lower, lower, or lower limb. superior, amputated and only in the United States, there are two million.
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