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A team of scientists from the American University of Tufts succeeded in partially regenerating the legs of amputated frogs by progesterone treatment using a portable bioreactor attached to the wound site , published today by Cell Reports magazine.
The results of this research can serve as a model for new cell stimulation therapies and allow advances in the treatment of amputation lesions in humans.
Certain species of the world. animals such as lizards or crabs are able to regenerate themselves by themselves, but this does not occur in the case of the African frog stud, known as Xenopus laevis and examined in this study. [19659002] This type of water frog is able to regenerate in its limbs during the early stages of his life, but he loses this ability at the age of
The researchers divided the frogs into three groups to perform their experiment and all sewed the portable bioreactor just to the wound left by the amputation .
Frogs Only One of the groups received progesterone through the bioreactor for 24 hours and researchers observed on them, for nine months, a partial regeneration of their unobserved extremities in the two other groups. .
"A very short application of the bioreactor and its payload (progesterone) caused months of growth and tissue structures" explained Michael Levin, one of the authors of the study and biologist at the Allen Discovery Center at the University of Tufts, Mbadachusetts (United States).
Frogs treated with progesterone showed over time partially regenerated legs, with bone, innervation and vas. Progesterone is a bad hormone known for its functions at the beginning and the beginning of pregnancy, but it has also been demonstrated. which promotes the repair of nerves, blood vessels and bone tissue.
"We examined progesterone because it seemed promising to promote nerve repair and regeneration, it also modulates the immune response to promote healing and triggers growth of blood vessels and bones", said neuroscientist Celia Herrero-Rincón, author of the study.
The next step for researchers is to perform a similar study on mammals and try to obtain more evidence that drug combination may constitute a new model for testing badtails therapeutics to induce the regeneration of non-regenerative species.
In the world there are millions of people who live with an end, inferior or superior, amputated and there are only two million in the United States.
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