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Imagine a snowball covered with these small brackets as golfers dig into the grbad to put the ball and give the first stick of each hole (called tees). Basically, it looks like an influenza virus (see below).
<p clbad = "canvas-atom text-canvas Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "So that our defenses can effectively fight a virus we must have d & # 39; antibodies that s & # 39; anchor to the highest form of these viral tees in s & # 39; incorporating like two puzzle pieces [19459005Aveclesvaccinsannuelscontrelagrippequenousfournissonsànosaînésetauxpersonnesàhautrisquenouspréparonsnosdéfensescontrelessoucheslespluscourantesquelesvirologuesobserventàchaquesaison"data-reactid="32">Pourquenosdéfensespuissentcombattreefficacementunvirusnousdevonsdisposer of antibodies that anchor to the higher form of these viral tees by sliding into them like two pieces of the puzzle . With the annual flu shots we provide to our seniors and high-risk people, we are preparing our defenses against the most common strains that virologists observe every season.
<p clbad = "canvas-atom-text-canvas Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "But as the flu is not not caused by a single virus, it is actually the product of a collection of generically diverse viruses that constantly mutate, our defenses are never fully prepared against this disease .This explains that despite vaccination campaigns, each year between 290,000 and 650,000 people die worldwide due to seasonal flu, according to figures from the World Health Organization. "data-reactid =" 33 "> But as the flu is not caused by a single virus, but is actually the product of a set of generically varied viruses that constantly mutate, our defenses are never perfectly prepared. this disease . This explains why, despite vaccination campaigns, between 290,000 and 650,000 people die each year in the world due to seasonal flu, according to figures from the World Health Organization.
<p clbad = "canvas-atom-canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "Is there anything that we can do? Yes, on the horizon, you can see a hope come from an iconic animal of South America: flames .And it is that these hairy inhabitants of the Andean highlands, belonging to the family of camelids, keep a great secret in their immune system, able to produce special antibodies that manage to cope with several influenza strains simultaneously. "data-reactid =" 34 "> Can we do something? Yes, on the horizon, the hope of an iconic animal of South America: Llamas . And do these fur-dwelling inhabitants of the Andean highlands, belonging to the family of camelids, keep a great secret for their immune system, which is capable of producing certain special antibodies that manage to resist several strains of flu simultaneously
<p clbad = "canvas-atom-canvas-text Mo (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "Indeed, in a A promising new study, these antibodies were used to attack several strains of influenza at the same time a technique that could allow more effective prevention of influenza, and these antibodies can survive longer without refrigeration, which could reduce the costs and complexity of treating flu. " data-reactid = "35"> Indeed, in a very promising new study, these antibodies were used to attack several strains of influenza at the same time technique that could allow more effective prevention of influenza . In addition, these antibodies can survive longer without refrigeration, which could reduce the cost and complexity of influenza treatment.
<p clbad = "canvas-atom-canvas-text Mb (1.0em) Mb (0) –sm Mt (0.8em) – sm" type = "text" content = "As always, it is necessary to demonstrate for the moment the study was performed on mice and we already know that the good results obtained with rodents can not always be extrapolated to humans, which , we must also recognize the good news, and the truth is that the results of the study showed lasting protection in older mice and immunodeficient against various influenza A and B viruses, even though they have received lethal doses. "data-reactid =" 36 "> As always, caution should be exercised. For the moment the study was performed on mice and we already know that the good results obtained with rodents can not always be extrapolated to humans. That said, we also need to recognize the good news and the truth is that the study results showed lasting protection in older mice and immunodeficient against various influenza A and B viruses, even though They received lethal doses.
<p clbad = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "Up to now, vaccines seasonal were based on the injection of fragments of the influenza virus (previously neutralized) to teach the immune system of the receptor to produce antibodies compatible with the external structure of the virus . vaccinated was found with the virus in nature, his antibodies were already ready to fight them, but unfortunately, given the speed at which these viruses mutate, this year's vaccine will no longer be useful year-round Next "data-reactid =" 37 "> Until now, seasonal vaccines have relied on the injection of fragments of the influenza virus (previously neutralized) to teach the immune system of the receptor to produce antibodies that fit into the external structure of the virus . virus . If the person vaccinated later found the virus in the wild, his antibodies were already ready to fight them. Unfortunately, given the speed with which these viruses mutate, this year 's vaccine will not do well next year.
Three-dimensional representation of the influenza virus. (Image credit: Pixnio.com).
<p clbad = "canvas-atom canvas-text Mo (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "However, l & # 39; The innovative approach of this team of biochemists from the Scripps Research Institution is to create a preventative treatment that could work year after year and potentially protect against seasonal flu and possible pandemics, such as fearful bird flu, explains the One of the co-makers of the book, Ian Wilson : "What we want, is to ignore the use of vaccines." Instead of asking the body to enhance its immunity, we used flame-derived antibodies to directly fight the flu virus. "" data-reactid = "58"> However, the innovative approach of this team of biochemists from the Scripps Research Institution is to create a preventive treatment that could work from year to year and potentially protect against both the seasonal flu and possible pandemics. , as the bird flu fears. It is explained by one of the co-leaders of the book, Ian Wilson : "What we want is to ignore the use of vaccines." Instead of asking the body to reinforce its immunity, we use flame-derived antibodies to directly fight the influenza virus. "
<p clbad =" canvas-atom-canvas-text Mb (1.0em) Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm "type =" text "content =" The new neutralizing antibody, called MD3606 was produced from samples previously taken in flames., Immunized with vaccines and exhibiting multidomain characteristics that is, it is able to protect itself simultaneously against different types of flu.After what I can read, the antibody delivered to the mice was obtained by the fusion of four different single-domain antibodies into a larger molecule, for which a human protein serving as a scaffold was used. "data-reactid =" 59 "> The new neutralizing antibody, which they called MD3606 was produced from samples taken from flames previously immunized with vaccines and presents of multidomain features that is, that it is able to simultaneously protect against different types of flu.After what I can read, the antibody administered to mice was obtained by fusing four different single-domain antibodies into a larger molecule, for which a human scaffolding protein was used.
<p clbad = "canvas-canvas-Text Mo (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "The work of the team co -directed by Wilson has just been published in Science . " data-reactid = "66"> The work of Wilson's team has just been published in Science .
I learned to read Pbs.org.
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