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The disappearance of the appendix is related to the decreased risk of Parkinson's disease in about 20% of cases. A large-scale epidemiological badysis involving more than one million people in Sweden showed that withdrawal from the appendix was badociated with a reduced risk of Parkinson's disease (PD) in almost 20% of cases which implies that this tiny organ could contribute to the onset of this disease.
Researchers have reported this finding, while asking for further epidemiological studies to confirm the results. effect of appendectomy on the risk of EP. PD, a common and incurable neurodegenerative disease, represents a considerable financial and health burden in the United States. UU., With a million people affected in the United States UU., That implied more than 14,000 million dollars in medical expenses in the country only in 2010.
According to forecasts, for the year 2040, the impact of EE in the EE will double. UU., Which highlights the urgent need to develop more effective interventions. Previous research has shown that abnormalities of the gastrointestinal tract are common in PD, which may precede motor symptoms by up to 20 years
. On this occasion, Bryan Killinger and his colleagues studied the link between EP and the appendix. , which contains large amounts of α-synuclein, a protein that adds to the brains of patients with PD. They studied a set of epidemiological data containing demographic information and statistical data on PE for 1.6 million people in Sweden, and discovered that appendectomy reduced the overall risk of developing a PE of 19.3%.
Interestingly, appendectomy has been badociated with greater risk-reduction effect among rural residents, suggesting that the effects of the procedure could neutralize environmental risk factors, such as Pesticide exposure, which has been badociated with an increased risk of PM. Analysis of a second set of data from 849 patients with PD revealed that the appendectomy was badociated with the late onset of PM at an average of 3.6 years later .
Killinger et al. they also examined the appendages of healthy individuals and found that they contained chemically active α-synuclein predisposed to harmful aggregation. According to the authors, therapies aimed at accumulating α-synuclein in the appendix and in the intestine should be studied as an early intervention strategy possible to reduce the risk of PD later in life. life.
Source: AAA
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