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AFP Agency
Paris / 17.07.2018 12:17:17
The Promising Experimental Technique of Genetic Publishing Crispr-Cas9 which is Used to Modify Genes defective, is less accurate than it was thought and causes unexpected mutations, according to a study.
These genetic scissors caused during some experiments ["important" and "frequent"] mutations in mice and in human cells, according to the study published in the journal Nature Biotechnology .
Its authors argue that the unintended changes that this technique causes in the DNA "has been largely underestimated up to here," said Allan Bradley, of the US. Wellcome Sanger Institute in England, where the study was conducted.
Crispr-Cas9 was an important Discovery in 2012, attributed to the Naco-American fra Emmanuelle Charpentier and Jennifer Doudna, often quoted in Nobel bets. It is based on an enzyme that acts as a "molecular scissors", able to remove the unwanted parts of a genome to replace them with new pieces of DNA ] as if he was correcting a typo. a word processing program.
The technique, in a state of research, has not yet been used in humans. But researchers have succeeded in correcting a genetic anomaly in human embryos, potentially opening the way to great advances in the treatment of genetic diseases not without posing great ethical questions. And it's theoretically, this technique could be used to create genetically modified babies in order to choose for example the color of their hair or increase their physical strength.
The study published on Monday showed changes in DNA of some cells that could activate or inactivate important genes. For Robin Lovell-Badge, of the Francis Crick Institute of London, the report confirms that in genetic publishing "it must be verified that the changes that are produced are only those desired".
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