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Stanford University experts have revealed the link between genetic information and disease.
Researchers at the Stanford University School of Medicine, in collaboration with other institutions, have identified a link between the proteins bind to deoxyribonucleic acid (DNA) and cancer development .
This discovery could provide information on the evolution of different types of cancer, said the university institution in a statement.
chromatin, the DNA-protein complex where all genes reside. Specifically, it evaluates the relationship between chromatin and transcription factors, proteins that play a crucial role in the management of activated genes in cells.
Some genes are turned on or off depending on how transcription factors are used. they bind to specific parts of the chromatin. The study found that these binding patterns and the resulting gene activation act as a key for different types of cancer, allowing researchers to understand the biology of this disease at its most basic level.
Among the authors include: Genetics specialists Howard Chang and William Greenleaf, as well as researcher Ryan Corces, said that to understand the origin of damaged genes in the case of cancer, they sought in the nucleus the process of transcription of the cell.
Exactly what does not work at the critical stage, the researchers used 410 tumor samples, representing 23 different types of cancer, and a new technique called transposase-accessible chromatin baday, by sequencing.
vaporize your DNA, but only accessible chromatin is painted, which gives researchers a quick and easy way to identify key areas of protein binding, "he said.
A discovery has shown that mutations can occur in the chromatin sequence, thus creating a new accessible site where a transcription factor can bind. "Once the protein has adhered to the site, a new gene is expressed that causes significant biological changes
Source: Mvs News
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