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COVID-19 mRNA vaccines have been a true medical revolution and have now immunized billions of people around the world. Although many mRNA vaccines have been in the works for years before COVID, the urgency of the pandemic has led to an influx of public and private support, which has led to the successful acceleration of such interventions.
But no medical intervention is without risks and despite its benefits, we must ask ourselves what these can be. Since the clinical trials, there have been discussions about side effects, most of them common with vaccination. From localized pain to fatigue and even nausea. But what about more serious and potentially fatal side effects? Some important answers to this question come from a new article published in JAMA. And that’s positive.
Moderna and Pfizer / BioNTech COVID-19 mRNA vaccines do not appear to lead to an increase in serious health problems. The research was conducted by federal and private insurance scientists and they looked at 23 specific serious and often fatal conditions. Among them were a heart attack, stroke, appendicitis, blood clot formation, Bell’s palsy, and Guillain-Barré syndrome.
Data from 6.2 million people were collected in the first six weeks after vaccination. And the incidence of serious health problems was compared between the first three weeks and the last three weeks. Serious conditions occur consistently in the population, but there is no evidence that they were caused by the vaccine – the incidence of serious results was not significantly higher in the first 21 days after vaccination than in the days 22 to 42 days after vaccination. The team also estimated the confirmed number of anaphylactic events to be around 5 per million vaccine doses injected.
While the study is encouraging about side effects, it has serious limitations. The team is frank that the power of statistical analysis on past data is not as good or as strong as it would be preferable. Other data will resolve this. There could be specific health outcomes not evaluated in this study that could be important, or some could have been missed if it took longer to manifest than the six weeks of the study.
It is also important to remember that this is not a long-term effects study and researchers can only estimate effects that have been brought to the attention of health care physicians in affected facilities. , resulting in a level of societal bias.
The research was funded by the Center for Disease Control as part of the Vaccine Safety Datalink (VSD). The initiative, launched in 1990, conducts research on important vaccine safety issues in large populations
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