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A new study found that women can significantly reduce their risk of breast cancer by eating all their meals within eight hours.
Restricting the time they eat rather than what they eat can "dramatically" reduce the growth of tumors, even when the food is high in fat.
Breast cancer is the most commonly diagnosed cancer in American women, according to breastcancer.org. About 1 in 8 women will develop invasive breast cancer in their lifetime.
In a recently published study, US scientists investigated whether the time-restricted diet of obese mice – where they only have access to food for eight hours instead of 24 hours a day – could improve metabolic health and reduce the risk of breast cancer development and growth.
In three different studies on mice, the results showed that limited meals had a dramatic effect.
In addition to delaying the development of tumors, it reduced tumor growth in obese mice fed a high-fat diet at the levels seen in lean mice.
The results also showed that the increase of insulin in the system increased the speed of tumor development while reducing it had the opposite effect.
The findings add to a growing body of evidence pointing to obesity and the metabolic syndrome, a set of risk factors that increase the risk of developing stroke and diabetes, are also risk factors for cancer, by postmenopausal breast cancer.
Dr. Manasi Das, Principal Investigator at the University of California San Diego, Postdoctoral Researcher, said, "Improving the metabolic health of postmenopausal women with obesity can reduce their risk of cancer." breast.
"To limit the harmful effects of obesity, it may be more effective than eating with minimal time, as hunger and irritability make it more difficult to maintain a restriction of long-term calories.
"The results suggest that the antitumor effect of time-limited consumption is at least in part due to lower insulin levels, suggesting that this intervention could be effective in preventing and treating breast cancer.
"Exploring the ability of a time-limited diet to prevent breast cancer could be an inexpensive but effective strategy to prevent cancer from reaching a wide range of patients and would represent a breakthrough in research." about breast cancer. "
The researchers conducted three experiments on mice without ovaries to simulate the postmenopausal state.
In the first study, the mice were made obese following a high fat diet for 60 weeks and then divided into two groups.
One group had access to food 24 hours a day, while the other group had access to food for 8 hours at night, when the mice were the most active.
Obese mice were compared to a group of mice fed a low-fat diet 24 hours a day.
Three weeks after the start of the restricted feeding program, breast cancer cells were injected into all rodents, and tumor growth was measured periodically.
In the second study, mice genetically modified to develop spontaneous breast cancer were divided into two groups: one was on a high-fat diet 24 hours a day, the other was on a high-fat, time-limited diet. , while tumor growth was measured periodically by ultrasound and also manually using a compass of thickness.
Insulin resistance – hyperinsulinemia – associated with obesity, a cancer-promoting factor and insulin dependence of tumor growth has been studied either by increasing insulin at Using an implanted insulin pump, either by reducing the secretion of insulin using the diazoxide agent.
For the third study, some mice receiving a low fat diet were implanted with an insulin pump, while others received saline as a control.
In a second approach, insulin was reduced by adding diazoxide to the diet of high-fat diet mice. Mice in the fat free diet without diazoxide were used for comparison and tumor growth was measured over time.
In these studies, time-limited feeding had a dramatic effect, delaying tumor development and reducing tumor growth in obese mice fed a high-fat diet at the levels seen in lean mice.
Mice implanted with an insulin pump showed faster tumor growth than the control group, and mice given insulin-reducing diazoxide had reduced tumor growth compared to controls.
The study was presented at ENDO 2019, the annual meeting of the Endocrine Society in New Orleans.
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