[ad_1]
Yoshihara, E. et al. ERRγ is required for the metabolic maturation of therapeutically functional glucose-sensitive β cells. Cell Metab. 23, 622–634 (2016).
Hrvatin, S. et al. Differentiated human stem cells look like fetal and non-adult β cells. Proc. Natl Acad. Sci. United States 111, 3038-3043 (2014).
Rezania, A. et al. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat. Biotechnol. 32, 1121-1133 (2014).
Pagliuca, FW et al. Generation of functional human pancreatic β cells in vitro. Cell 159, 428–439 (2014).
Kieffer, TJ Close on the Mass Production of Mature Human Beta Cells. Cell stem cell 18, 699–702 (2016).
Liu, JS & Hebrok, M. All mixed up: role definition for β cell subtypes in mature islets. Genes Dev. 31, 228-240 (2017).
Takebe, T. et al. Vascularized and functional human liver from an organ bud transplant derived from iPSC. Nature 499, 481-484 (2013).
Asai, A. et al. Paracrine signals regulate the maturation of human hepatic organoids from induced pluripotent stem cells. Development 144, 1056-1064 (2017).
Bader, E. et al. Identification of proliferative and mature β cells in the islets of Langerhans. Nature 535, 430–434 (2016).
van der Meulen, T. et al. Urocortin3 is involved in the somatostatin-dependent negative feedback control of insulin secretion. Night. With. 21, 769–776 (2015).
Blum, B. et al. The functional maturation of beta cells is marked by an increase in the glucose threshold and by the expression of urocortin 3. Nat. Biotechnol. 30, 261-264 (2012).
van der Meulen, T. et al. Urocortin 3 labels the alpha and beta pancreatic cells of the mature human and embryonic pancreas. PLoS ONE 7, e52181 (2012).
Prentki, M., Matschinsky, FM & Madiraju, SR Metabolic signaling in fuel-induced insulin secretion. Cell Metab. 18, 162-185 (2013).
Huang, SM et al. Inhibition of tankyrase stabilizes the axin and antagonizes Wnt signaling. Nature 461, 614–620 (2009).
Baas, M. et al. TGFβ-dependent expression of PD-1 and PD-L1 control CD8+ T lymphocyte anergy in transplantation tolerance. eLife 5, e08133 (2016).
Martinov, T., Spanier, JA, Pauken, KE & Fife, BT PD-1 regulation mediated by the islet-specific CD4 pathway+ T cell subsets in autoimmune diabetes. Immunoendocrinology 3, e1164 (2016).
Keir, ME et al. Tissue expression of PD-L1 mediates tolerance of peripheral T cells. J. Exp. Med. 203, 883–895 (2006).
Ansari, MJ et al. The programmed death pathway-1 (PD-1) regulates autoimmune diabetes in non-obese diabetic (NOD) mice. J. Exp. Med. 198, 63–69 (2003).
Ma, D. et al. A deficiency of PD-L1 in the islets reduces the survival of allografts in mice. PLoS ONE 11, e0152087 (2016).
Rui, J. et al. Β cells that resist immunological attack develop during the progression of autoimmune diabetes in NOD mice. Cell Metab. 25, 727–738 (2017).
Wang, CJ et al. Protective role of programmed ligand 1 (PD-L1) death in non-obese diabetic mice: the paradox in transgenic models. Diabetes 57, 1861-1869 (2008).
Colli, ML et al. PDL1 is expressed in the islets of people with type 1 diabetes and is upregulated by α and γ interferons via IRF1 induction. eBioMedicine 36, 367–375 (2018).
Osum, KC et al. Interferon-gamma causes programmed expression of death ligand 1 on islet β cells to limit T cell function during autoimmune diabetes. Sci. Representative. 8, 8295 (2018).
Eizirik, DL & Mandrup-Poulsen, T. A choice of death – immune-mediated beta-cell apoptosis signal transduction. Diabetology 44, 2115-2133 (2001).
Russ, HA et al. Controlled induction of human pancreatic progenitors produces functional beta-type cells in vitro. EMBO J. 34, 1759–1772 (2015).
Nair, GG et al. Recapitulation of the pooling of cultured endocrine cells promotes maturation of β cells derived from human stem cells. Nat. Cellular biol. 21, 263-274 (2019).
Sneddon, JB et al. Stem cell therapies for treating diabetes: progress and challenges ahead. Cell stem cell 22, 810–823 (2018).
Zhou, Q. & Melton, DA Regeneration of the pancreas. Nature 557, 351–358 (2018).
Turner, M. et al. Towards the development of a world bank of induced pluripotent stem cells. Cell stem cell 13, 382-384 (2013).
Morizane, A. et al. MHC pairing enhances the transplantation of iPSC-derived neurons in non-human primates. Nat. Common. 8, 385 (2017).
Wei, Z. et al. Vitamin D changes BAF complexes to protect β cells. Nat. Common. 173, 1135-1149 (2018).
Yoshihara, E. et al. Disruption of TBP-2 improves sensitivity and insulin secretion without affecting obesity. Nat. Common. 1, 127 (2010).
Buenrostro, JD, Wu, B., Chang, HY & Greenleaf, WJ ATAC-seq: a method for testing the accessibility of chromatin at the genome scale. Curr. Protoc. Mol. Biol. 109, 21.29.1-21.29.9 (2015).
Google Scholar
Heinz, S. et al. Simple combinations of lineage-determining transcription factors cis– regulatory elements required for the identities of macrophages and B cells. Mol. Cell 38, 576-589 (2010).
Dobin, A. et al. STAR: ultra-fast RNA-seq universal aligner. Bioinformatics 29, 15–21 (2013).
Trapnell, C. et al. Differential analysis of gene regulation at transcript resolution with RNA-seq. Nat. Biotechnol. 31, 46–53 (2013).
Roberts, A., Pimentel, H., Trapnell, C. & Pachter, L. Identification of novel transcripts in annotated genomes using RNA-seq. Bioinformatics 27, 2325-2329 (2011).
van Dijk, D. et al. Retrieving gene interactions from unicellular data using data diffusion. Cell 174, 716–729 (2018).
Macosko, EZ et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202–1214 (2015).
Butler, A., Hoffman, P., Smibert, P., Papalexi, E. & Satija, R. Integration of single-cell transcriptomic data under different conditions, technologies and species. Nat. Biotechnol. 36, 411–420 (2018).
Huang da. W. et al. Extract biological significance from large lists of genes with DAVID. Curr. Protoc. Bioinformatics Ch. 13, https://doi.org/10.1002/0471250953.bi1311s27 (2009).
Walter, W., Sánchez-Cabo, F. & Ricote, M. GOplot: an R package for visually combining expression data with functional analysis. Bioinformatics 31, 2912-2914 (2015).
[ad_2]
Source link