Checking for Heart Damage Can Predict Risk of Pakinson Later

New York: According to the researcher, the examination of stress and inflammation in the heart could be the key to predicting the risk of Parkinson's disease because it could help doctors test for new therapies and to delay the progression of the disorder. the time when Parkinson's patients are diagnosed – usually according to tremors and motor control symptoms – about 60% of them also have serious damage to the heart's connections to the sympathetic nervous system.

When they are healthy, these nerves stimulate the heart to speed up its pumping in order to adapt to rapid changes in activity and blood pressure.

"This neural degeneration of the heart means that patients' bodies are less prepared for stress and simple changes. like getting up. They increased the risk of fatigue, fainting and falling which can cause injury and complicate other symptoms of the disease, "said Marina Emborg, of the University of Wisconsin-Madison, United States.

For the study, published in the journal npj Parkinson Disease, teams used Rhesus macaque monkeys as models for the symptoms of Parkinson's disease, who received doses of neurotoxins that caused damage to the nervosa in their heart in the same way that Parkinson's disease affects human patients.

The team discovered that radioligands can also be used to test the effectiveness of new treatments to protect the neurons that regulate the activity of the heart of patients.

"We know that there is damage to the heart in Parkinson's disease, but we have not been able to see exactly what causes it.Now we can visualize in detail where the Inflammation and oxidative stress occur in the heart, and how it relates to how Parkinson's patients lose these neuronal connections in the heart, "said lead author Jeanette Metzger.