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in Washington DC [USA]: According to a new study, people with Alzheimer's disease treated with Antidiabetic drugs had significantly fewer markers of the disease, including abnormal microvasculature and a deregulated gene expression in their brain compared to patients treated with the help of other types of drugs.
The study was conducted by researchers at the Mount Sinai School of Medicine, the results of which were published in the journal "PLOS One & # 39 ;. [19659002] This is the first study to examine what is happening in the pathways of brain tissue and endothelial cells, the cells lining the blood vessels in the brains of patients with the disease. Alzheimer treated with antidiabetic drugs. The results of the study will help future studies on Alzheimer's disease and potential new therapies targeting specific cells, as they suggest that targeting the brain's capillary system could have beneficial effects on the brain. patients with Alzheimer's disease.
Many older people with diabetes have brain changes that are characteristic of Alzheimer's. Despite this link, two previous studies on brain tissue performed on Mount Sinai showed that the brains of people with Alzheimer's disease and diabetes exhibited fewer Alzheimer's lesions than those of people with Alzheimer's disease. Alzheimer's disease sufferers without diabetes.
The results suggested that antidiabetic drugs had a protective effect on the brains of patients with Alzheimer's disease.
To determine what is happening at the molecular level, the research team has developed a method for separating brain capillaries from the brain tissue of 34 people with type 2 diabetes and Alzheimer's . treated with anti-diabetes drugs and compare them to brain tissue of people with Alzheimer's disease and 19 brains of people without Alzheimer's disease or diabetes.
The researchers then examined the vessels and brain tissue separately to measure changes in Alzheimer's molecular RNA markers for capillary brain cells and insulin signaling.
of these markers were reduced in vessels and brain tissue in the group with Alzheimer's and diabetes. The vast majority of RNA changes observed in Alzheimer's disease were absent in patients with this disease who had been treated with antidiabetic drugs.
"The results of this study are important because they give us new information for the treatment of Alzheimer's disease," said lead author of the study, Vahram Harutunian.
"The Most modern treatments for Alzheimer's disease target amyloid plaques and have failed to effectively treat this disease, and seem to have a beneficial effect on people with Alzheimer's disease. conducting research trials of people using drugs that are similar or have similar effects on the biological pathways of the brain and the types of cells identified in this study, "said Dr. Haroutunian.
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