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Washington DC, July 17: Obesity-derived chili pepper drug caused long-term weight loss and better metabolic health in mice eating a high-fat diet.
The University of Wyoming Metabocin, was based on capsaicin – the compound that gives chilies their spicy burn.
It was designed to slowly release capsaicin throughout the day so that it can exert its anti-obesity effect without producing inflammation or unwanted side effects. "We have seen marked improvements in blood sugar and cholesterol, insulin response, and symptoms of fatty liver," says Dr. Baskaran Thyagarajan, lead researcher, describing how Metabocin reversed many of the harmful effects of the rich diet. in fats.
The team has developed Metabocin, which can be taken orally, to target receptors called TRPV1 (subfamily of potential transient 1 vanilloid receptors) that are found in high numbers in fat cells. By stimulating TRPV1 receptors, white fat cells begin to burn energy instead of storing it, which in theory should lead to weight loss.
An important question for researchers is whether the drug remains effective the effects would outweigh its benefits. The mice in this experiment stayed on the drug for 8 months, maintaining weight loss without evidence of safety problems. Other current experiments will see how long this can be maintained.
"It was safe and was well tolerated by mice," Thyagarajan concluded. "The development of Metabocin as an anti-obesity treatment is promising as part of a robust strategy to help people coping with obesity."
Although these findings may give some people the chance to become obese. idea to eat more spicy foods to lose weight work as expected. Most of the capsaicin in spicy foods is not well absorbed into the body and therefore would not produce these effects. The researchers specifically modified capsaicin in Metabocin for adequate absorption and sustained release.
The findings were presented at the 26th annual meeting of the Society for the Study of Ingestive Behavior.
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