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Scientists have found that the administration of gene therapy can reverse the damage in kidney cells, suggesting a potential treatment for chronic kidney disease characterized by the gradual loss of its functions.
Research has shown that if the adeno-badociated virus is a parent of the virus that causes colds – could provide genetic material to damaged cells in the kidneys.
They explained that diabetes, hypertension, and other conditions cause chronic kidney disease, which occurs when damaged kidneys can not effectively filter out excess waste and fluid from the body.
"Chronic kidney disease is a huge and growing problem. Over the years, we have not developed more effective drugs for this disease, and this reality leads us to explore gene therapy, "said Benjamin D. Humphreys of the Division of Nephrology at the University. from Washington to the United States
. published in the Journal of the American Society of Nephrology, the team evaluated six AAV viruses, both natural and synthetic, in mice and human organo-derived stem cells.
A synthetic virus, Anc80, created by researchers by reaching two types of cells that contribute to chronic kidney disease by secreting proteins that gum the organ and cause irreversible damage.
The results showed that Anc80-borne genetic material was successfully transferred to targeted kidney cells and the same virus was also used in gene therapy strategies to treat mice with renal scarring.
"The interesting thing about adeno-badociated viruses is that they persist in the body," says Humphreys.
"Chronic kidney disease is a slowly progressing disease, so it's a After many years of research, we could imagine that patients would need injections twice a year rather than weekly, as with chemotherapy, "adds Humphreys.
– IANS
sh / rt / mag / vm
(This story was not edited by Business Standard staff and is generated automatically from a syndicated feed.)
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