Gut microbiota products could promote diabetes

The study was published in the Journal of Cell

Representational Image

A new study found that the gut microbiota, which is the community complex of microorganisms living in the human digestive tract and other animals, has an ability to influence the response of cells to insulin and can therefore contribute to type 2 diabetes.

The study was published in the Journal of Cell. Scientists from the Sahlgrenska Academy of the University of Gothenburg, Sweden, have shown that the gut microbiota of people with type 2 diabetes mellitus at treatment could be linked to a metabolism different from the other. histidine, an amino acid mainly derived from the diet. [19659005] In recent years, the gut microbiota has been badociated with health and several diseases. However, only a few studies have examined whether an altered gut microbiota could directly affect the disease

which resulted in the formation of imidazole propionate, a substance that impairs the ability of cells to respond to insulin.

Reducing the amount of imidazole propionate produced by bacteria could therefore be a new way of treating patients with type 2 diabetes.

"This substance does not cause all type 2 diabetes, but our working hypothesis is that there are subpopulations of patients Fredrik Backhed, professor of molecular medicine, whose work focuses on the role of gut microbiota in metabolism, said Fredrik Backhed, professor of molecular medicine, in order to reduce the risks of dietary modification or gut microbiota with the aim of reducing levels of imidazole propionate.Analysis of various substances in the blood vessel from the intestine to the liver. researchers then identified a high concentration of imidazole propionate in patients with type 2 diabetes.

Using samples Fecal it was also possible to show that the microbiota of people with type 2 diabetes produced imidazole propionate when the addition of histidine was added. This mechanism was not found in control subjects without diabetes.

The study included five patients with type 2 diabetes and ten control subjects without diabetes. The results were then confirmed by a larger study of 649 people

. The scientists from Gothenburg then studied the effect of imidazole propionate on sugar metabolism and discovered that the molecule affected a signaling pathway previously linked to metabolic-related diseases by directly activating a specific protein, p38gamma.

These results made it possible to answer questions about the nature of the underlying mechanisms. According to Backhed, these often remain unanswered in studies of how intestinal bacteria are badociated with, for example, obesity, diabetes, and cardiovascular disease.

"Our results clearly show how important it is to understand the interaction between the gut microbiota and the diet, our metabolism in health and disease." The result also shows that the intestinal bacteria of different individuals can lead to the production of totally different substances that can have very specific effects on the body, "said Backhed.

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