[ad_1]
In fact, a higher dose of rifampicin, an antibiotic to treat several types of bacterial infections, can kill more TB bacteria in sputum cultures without increasing the undesirable effects of treatment.
A study by the American Thoracic Society that the results were particularly encouraging because they suggest that a sufficiently high dose of rifampicin daily could reduce the duration of treatment.
"Six months of treatment with four drugs – often provided with support and supervision – represent a significant burden to the health care system, as well as to the patient. Patients who can not complete the full course of treatment do not can not be cured. "said Dr. Gustavo E. Velasquez, co-author of the study.
Optimizing the dosage of rifampicin was considered a priority because it had been # 39; sterilizing effect the most powerful of the four drugs.
The trial participants showed that each increase of 5 mg / kg per day of rifampicin increased the rate of elimination of tuberculosis bacteria sputum. The study also examined rifampicin concentrations in plasma and found that the elimination rates of TB bacteria were significantly related to higher rifampicin concentrations. [1] 9659002] The increased effectiveness of higher doses did not appear to result in grade 2 or higher adverse events.
The findings are published in the Journal of American Journal of Respiratory and Critical Care Medicine
(This story was not edited by the staff of Business Standard and is generated automatically from one source. syndicated flow.)
[ad_2]
Source link
