Knowing how obesity can cause the early onset of Alzheimer's disease

Toronto, June 30: While aging has long been identified as a major risk factor Alzheimer's, a new study shows that obesity at age can contribute to the early development of brain disorder, called the most common form of dementia.

The results showed that aging, combined with a diet high in fats and sugars, increases the inflammation and stress of the hippocampus – responsible for long-term memory – and the prefrontal cortex – responsible for complex cognitive, emotional and behavioral functions.

It is believed that both brain regions are involved in the progression of Alzheimer's disease.

"This study provides new information regarding the mechanical link between obesity and the pbadage from middle-aged to middle-aged adults and the signaling cascades that may be related to the pathology ( Alzheimer's) later in life, "said Rebecca EK MacPherson, Brock University, Ontario, Canada.

In the study, published in the journal Physiological reports, the team used a mouse model to study the effects of a diet inducing obesity on the signaling of the disease. 39; insulin. tells the body how to use sugar – and markers of inflammation and cellular stress.

A group of mice received a high fat and high sugar diet ("HFS"), while the control group had a normal diet. 19659004] Mice with HFS demonstrated significantly higher markers of inflammation, insulin resistance and cellular stress in the hippocampal areas that would be involved in the progression of the Alzheimer's disease.

The study also revealed that some regions of the brain react differently to the risk factors badociated with Alzheimer's disease.

"These results complement our basic knowledge of the pathways involved in the early progression of pathogenesis (Alzheimer's). effects of a HFS diet on both the prefrontal cortex and the hippocampal regions, "said MacPherson.