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Sung Kyun Park
The accumulation of lead in the tibia was badociated with resistant hypertension, according to a study published in the Journal of the American Heart Association . .
"Once the lead enters the body, it is very difficult to remove it" Sung Kyun Park, ScD, MPH, badociate professor in the departments of epidemiology and sciences of the Environmental Health of the University of Michigan. of public health, said Cardiology Today. "There are several decades left in your hard bones. As you get older and your bones weaken, lead can be released into the bloodstream and interfere with blood pressure control. Therefore, the most important implication of our clinical and public health study is to prevent lead exposure very early in life. "
To examine the risk of resistant hypertension in relation to lead levels in bones, the researchers conducted a prospective cohort study on the study's Normative Ageing Study. Veterans Affairs, a longitudinal cohort study of 475 male volunteers aged 21 to 80 years (97% whites)
Data on systolic blood pressure, diastolic blood pressure, antihypertensive drugs, lead in the blood, lead in the patella, lead in the tibia and demographic and confounding variables were taken into account
140 mm Hg or diastolic blood pressure greater than 90 mm Hg in three patients or requiring more than four drugs for blood pressure control
In the cohort, 20.4% of participants had resistant hypertension, with median tibia and patella concentrations of 20 μg / g and 25 μg / g, respectively
The researchers found an badociation between resistant hypertension and interquartile lead tibia increase (IQR) between 13 μg / g and 28.5 μg / g (RR = 1.19; 95% CI, 1.01-1.41).
No badociation between resistant hypertension and patella by increase in IQR, defined between 18 μg / g and 40 μg / g (RR = 1.1, 95% CI, 0.92- 1,31), has not been established. No relationship was also observed between resistant hypertension and blood lead levels (RR = 1.11, 95% CI, 0.88-1.4).
"Our study should be replicated in other populations," Park said in an interview. "We also want to check in the future if a dietary intervention, such as calcium intake or physical activity, can lessen the observed effect of lead on resistant hypertension. . " – Melissa J. Webb
For more information:
Sung Kyun Park, ScD MPH,
can be contacted at [email protected] .
Disclosure s : The authors do not report any relevant financial disclosure.
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