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The researchers identified a natural lipid – a waxy fatty acid – used by a pathogenic bacterium to alter the host's immune response and increase the risk of infection.
According to researchers, including Schwarz B of the National Institutes of Health (NIH) in Hamilton, inadvertently they may have found a powerful therapy for inflammation against bacterial and viral diseases.
Lipids are known to help the bacterium Francisella tularensis – the cause of tularemia – to suppress host inflammation during the infection of human and mouse cells.
The results, published in the Journal of Innate Immunity, found a form of lipid Phosphatidylethanolamine, or PE, present in the bacterium.
The PE composition found in F. tularensis differs from that of PE found in other bacteria. In cell culture experiments, researchers found that the natural and synthetic form of EP reduced inflammation caused by tularemic bacteria and the dengue virus
Tularemia is a life-threatening disease transmitted to humans by contact with an infected animal. by the bite of a mosquito, a tick or a deer fly.
Although tularemia can be successfully treated with antibiotics, it is difficult to diagnose, mainly because the bacterium Francisella tularensis can suppress the human immune response,
Dengue fever, mainly transmitted by Aedes aegypti mosquitoes is rarely fatal but usually leads to high fever, severe headaches and pain throughout the body. There is no specific treatment for dengue, they add.
The researchers, after identifying PE as the lipid that impairs the immune response, began to consider its potential therapeutic value. Because Francisella tularensis is naturally highly infectious and therefore difficult to work with, the group has developed synthetic lipids – PE2410 and PEPC2410 – that would be much easier to study and produce.
The researchers then verified that both synthetic lipids also suppress the immune response during human and mouse cell infection in the laboratory.
Both versions inhibit the immune response to the immune response seen in infected but untreated cells. says
– IANS
vc / mag / vm
(This story was not edited by Business Standard staff and is generated automatically from a syndicated feed.)
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