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New York, July 7 (IANS): Researchers have identified a natural lipid, a waxy fatty acid used by a pathogenic bacterium to alter the host's immune response and increase the risk of disease. 39; infection.
According to researchers, including Schwarz B of the National Institutes of Health (NIH) in Hamilton, inadvertently they may have found a potent inflammation therapy against bacterial and viral diseases.
Lipids are known to help bacteria Francisella tularensis the cause of tularemia to suppress host inflammation during infection of human cells and the mouse.
The results, published in the Journal of Innate Immunity, found a form of lipid Phosphatidylethanolamine, or PE, present in the bacterium. in F. tularensis differs from PE found in other bacteria. In cell culture experiments, researchers found that the natural and synthetic form of EP reduced inflammation caused by tularemic bacteria and the dengue virus
Tularemia is a life-threatening disease transmitted to humans by contact with an infected animal. by the bite of a mosquito, a tick or a deer fly.
Although tularemia can be successfully treated with antibiotics, it is difficult to diagnose, mainly because Francisella tularensis bacteria can inhibit the immune response in humans. Fever, mainly transmitted by Aedes aegypti mosquitoes, is rarely fatal but usually causes high fever, severe headaches and pain throughout the body. There is no specific treatment for dengue, they add.
The researchers, after identifying PE as the lipid that impairs the immune response, began to consider its potential therapeutic value. Because Francisella tularensis is highly contagious and therefore difficult to work with, the group has developed synthetic lipids – PE2410 and PEPC2410 – that would be much easier to study and produce.
The researchers then verified that both synthetic lipids suppressed immune response during the infection of mouse and human cells in the laboratory.
Both versions inhibited the immune response to the immune response observed in infected but untreated cells, according to the researchers.
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