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Roorkee, Jul 10 (IANS): Researchers at the Indian Institute of Technology (IIT) Roorkee have identified a new immunomodulatory function of a protein that could potentially help in the treatment of sepsis and other inflammatory diseases caused by abnormal functions of
"The abnormal functions of immune cells are badociated with many pathological conditions such as severe sepsis (blood infection) and other inflammatory diseases. During sepsis, an uncontrolled infection leads to abnormal activation and localization of important immune cells such as neutrophils and macrophages, "said lead author Pranita P Sarangi, an badistant professor at IIT Roorkee.
The researchers said that a dysfunctional immune response leads to the deposition of these cells in visceral organs such as lice. mons, kidneys and liver. death.
Sometimes the use of antibiotics against infections could even make the situation worse by releasing broken components. In an animal model of sepsis, the full-length Fibulin-7 (Fbln7) protein and its C-terminal fragment (Fbln7C) inhibited the infiltration of macrophages and neutrophils into the blood, which stimulates the activation of immune cells. The data, published in the journal FASEB, demonstrated that Fbln7 and its shorter bioactive fragments or peptides may have therapeutic potential for the treatment of immunopathological conditions, which require downregulation.
The researchers said that currently, more research is being done on this aspect.
"Our immune system is composed of varieties of white blood cells (leucocytes) or leucocytes.In response to any inflammatory and infectious stimuli, leukocytes that move through the blood vessels react immediately by migrating to the affected site. from the blood vessel and through the tissue spaces, activated white blood cells interact with extracellular matrix proteins such as collagen, fibronectin, etc. ", says Sarangi." Immune cells bind to these proteins via their molecules. These cellular matrix communications via integrin receptors not only support migration, but also modulate various functions of immune cells, "she adds.
Fibroids are a group of glycoproteins often badociated with elastic fibers, basement and blood membranes.
Fbln7 has been ident It is the last member of the fibulin family in the development of the functioning of the teeth as a molecule of cell adhesion and has the ability to interact with other proteins, receptors and growth factors. the matrix. is also expressed in the privileged immune tissues such as eyes and placenta, but its functional significance was not known.
In our study using human peripheral blood monocytes and an endotoxin-induced systemic inflammatory mouse model, we showed that Fbln7 and Fbln7C could inhibit the adhesion, migration, and production of inflammatory molecules from monocytes and macrophages, the researchers said.
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