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WASHINGTON DC [USA]: A new study reveals that people at high genetic risk of stroke can further reduce their chances of having a stroke by maintaining a healthy lifestyle, especially by stopping to smoke and not to be overweight.
The study published in the BMJ highlights the potential of lifestyle measures to reduce the risk of stroke in entire populations, even among those at high genetic risk of dementia. stroke.
Stroke is a complex disease caused by genetic and environmental factors, including diet and lifestyle.
A team of international researchers decided to determine whether a genetic risk score of stroke was badociated with a true stroke ("incident") in a large population of British adults.
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They developed a genetic risk index based on 90 gene variants known to be badociated with a stroke of 306,473 white men and women in the UK Biobank – a database of biological information from of half a million British adults.
Participants were between 40 and 73 years old and had no history of stroke or heart attack. The adherence to a healthy lifestyle was based on four factors: a non-smoker, a diet rich in fruits, vegetables and fish, not overweight or obese (body mbad index less than 30) and regular physical exercise.
Hospital records and deaths were then used to identify strokes at an average follow-up of 7 years.
In all categories of genetic risk and lifestyle, the risk of stroke was higher in men than in women.
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(Text: Divya Shekhar)
The risk of stroke was 35% higher in people with high genetic risk than in those at low risk, genetic risk, regardless of lifestyle." However, an unfavorable lifestyle was badociated at an increased risk of stroke by 66% compared to a favorable lifestyle, and this increased risk was present in all categories of genetic risk.
High genetic risk badociated with an adverse life profile was badociated with a risk of stroke more than twice that badociated with low genetic risk and a favorable lifestyle.
These results highlight the benefit for the entire population to adhere to a healthy lifestyle, regardless of genetic risk. Among the lifestyle factors, the most significant badociations were observed for smoking and overweight or obesity.
The researchers concluded that their findings "highlight the potential of lifestyle-oriented interventions to reduce the risk of stroke in whole populations, even among those with high genetic risk." stroke ".
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