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Washington: According to a recent study, a subgroup of patients with low-risk bad cancer is unlikely to see their cancer recur after bad-conserving surgery, but can still reduce this risk through to radiotherapy.
Follow-up data from the only prospective randomized trial comparing post-treatment recurrence outcomes for low-risk in situ ductal carcinoma (DCIS) were presented at the 60th Annual Meeting of the American Society for Radiation Oncology (ASTRO) .
In In this long-term update, patients presenting with a "good risk" DCIS, defined by the research team as a cancer discovered only during a mammogram or accidentally during the course of a study. A bad biopsy for another reason, continued to present an extremely low recurrence 12 years after bad conservation surgery. The lowest recurrence rates were seen in patients who received whole bad radiotherapy (WBRT) and those who also chose to take tamoxifen.
"I think the most surprising thing was that the recurrence rate in patients randomized to receive radiotherapy was so low. Radiation reduced recurrence by more than 70%, which was a much deeper impact than expected, "said lead researcher Beryl McCormick.
None of the recurrent tumors in one or the other group appeared to pose a lethal risk. However, Dr. McCormick stated that it was reasonable for patients to determine, in consultation with their doctor, whether they wished to continue treatment after surgery.
"All DCIS are not identical, this type of cancer will not be effective. impact on life expectancy. We have found that radiation significantly reduces the risk of recurrence, but you start with an extremely low recidivism rate, even without radiation. Therefore, the patient and the physician should seriously discuss whether the patient wishes to continue additional treatment, "said Dr. McCormick.
DCIS is a cancer of the cells lining the milk ducts of the bad. It accounts for about one-quarter of all new bad cancers in about 60,000 cases diagnosed in the United States each year.
Eligible tumors were 2.5 cm or less, with margins of three millimeters or less and or grade Intermediate nuclear
The badysis included long-term follow-up data for 629 patients with a median age of 58 years, 76% of whom were postmenopausal women. 0.60 cm (61% 0.5 cm or less, 65% with a margin width of 1.0 cm or greater or a completely negative re-excision specimen) The highest nuclear tumor grade was 1, found c hez 44% of patients Grade 2 tumors were diagnosed in the remaining 56%.
In the next five years after surgery, Dr. McCormick noted "a slight increase in the local recurrence rate." For those who received RTW, this rate increased by just under 1%, to almost 3%. one hundred post-operative. For those who did not receive radiation, the recidivism rate increased by one percentage point per year of additional follow-up, from just under 7% to just under 12 % after 12 years.
Neither age nor the size of the pathological tumor. was significant in predicting local recurrence or local invasive recurrence.
Source: ANI
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