Shifts: Working in night shifts? This can increase the risk of heart disease, cancer and stroke



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WASHINGTON: Scientists, including one of Indian descent, have discovered that night work increases the risk of developing obesity and diabetes, which can lead to heart disease, stroke

and cancer.

The research, conducted by scientists from the Washington State University in the United States, dispelled the belief that the day-night cycle of the body is led by the master clock of the brain and revealed that biological clocks separated in the liver. and the pancreas has a clean mind.

"Nobody knew that biological clocks in people's digestive organs are so deeply and quickly changed by shift work schedules, even though the main brain clock barely fits these hours, "says Hans Van Dongen of WSU.

"As a result, some biological signals in the bodies of shift workers say that it is daytime while other signals say that it is night, which causes a disruption of metabolism" , he said.

"We believe that ours is the first study to suggest a mechanism for the connection between shift work and chronic kidney disease," said WSU professor Shobhan Gaddameedhi.

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The research also has implications for the study of other chronic diseases that shift workers are inclined to include, chronic kidney disease and bad cancer, skin and prostate.

Researchers have stated, however, that it is important to unravel the link between shiftwork and mentality.

"It is possible that changes in the metabolism of shiftworkers are badociated with an alteration in the activity of cellular processes that could be involved in cancer development later in life," Gaddameedhi said.

"Once we understand these cellular processes, we could potentially identify the genes involved and use that knowledge to find ways to prevent cancer in shiftworkers," he added.

The study badyzed blood samples of metabolites – products of chemical reactions involved in digestion – from blood samples of 14 healthy volunteers who had just completed a simulated schedule or a simulated night schedule.

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<p>  They found that, according to the night time schedule, the 24-hour rhythms digestive – related metabolites had changed by 12 full hours, although the master biological clock in the participants' brains had moved only about two hours.
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<p>  "Twenty-seven metabolites followed a 24-hour rhythm during simulated night and day schedules," said Debra Skene, a professor at the University of Surrey in the UK.
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<p>  "Of these, 24 showed a dramatic lag of 12 hours after the simulated night work schedule, which was not observed after the daytime schedule, which indicates that only three days of night work have the potential to disrupt metabolism, "she said.<br />
"Identifying the disrupted metabolic pathways will help unravel the mechanisms that underlie shift work and metabolic disorders," said Skene.
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