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million. Rajanish Giri, Assistant Professor of Biotechnology, IIT Mandi and his research team
Indian Institute of Technology (IIT) Mandi said that his researchers had identified dark regions in the proteins of Chikungunya Virus , which could help understand the molecular basis of infection and have implications in designing drugs to treat chikungunya.
The IIT Mandi study was undertaken by Dr. Rajanish Giri, badistant professor of biotechnology at the Faculty of Basic Sciences, with the aim of understanding the structure and action of chikungunya virus (CHIKV) by means of computer studies.
Assisted by researchers Ankur Singh, Ankur Kumar and Rakhi Yadav, collaborated with Dr. Vladimir Uversky of the University of South Florida to unravel the non-structural biology or dark proteome of the virus through computer studies.
In addition, the group also identified the molecular recognition characteristics (MoRF) of the virus.
These results have recently been published in the scientific reports (Nature Publishing Group) and in the open access journal of the Royal Society of Chemistry, RSC Advances.
"The pathogenic mechanism of CHIKV transmitted by arthropods is not yet fully understood because of the sacristy of information on the structure and non-structure of viral proteins." Our research seeks to fill this gap in the literature. knowledge, "said Dr. Giri.
"We believe that the badysis of CHIKV protein interactions from MoRF may help to understand the molecular mechanisms of the pathogenicity of this virus," he added.
The team used several computer tools to identify MoRF in CHIKV proteins.
The team found that all CHIKV proteins had at least one crucial MoRF for signaling events during the survival and pathogenesis of the virus.
Dr. Giri hopes that once all the molecular mechanisms of CHIKV proteins have been deciphered and that protein-protein interactions are understood, the way forward to design specific drug molecules capable of acting against this virus would be better.
The World Health Organization (WHO) reports that more than 1.5 million deaths worldwide are caused by viral infections each year. Since 320,000 mammalian viruses can potentially infect humans, the hope of humans to prevent and treat virus-transmitted diseases relies on a rigorous research enterprise.
Indian Ocean, Caribbean and Americas in recent years
This is India's second major advance this week in the treatment of chikungunya. A recent study of Professors Shailly Tomar and Pravindra Kumar of the Biotechnology Department of IIT Roorkee showed that a protein found in tamarind seeds had antiviral properties and could potentially be used to develop an antiviral drug for the chikungunya.
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