The P2X4 receptor helps cure multiple sclerosis

Washington DC, July 22: A receptor known as P2X4 enhances the body's repair responses when it s'. is multiple sclerosis.

Multiple sclerosis is an autoimmune disease that attacks and destroys a structure called "myelin sheath", the integrity of which is essential for the proper functioning of the brain and spinal cord

. A recent study has shown that this receptor microglial cells that increase their anti-inflammatory potential to reduce damage in multiple sclerosis and, most importantly, encourage the body's own repair responses.

During the progressive phase of the disease, it is the microglial cells in the brain that are the main cause of chronic inflammation responsible for neurological deterioration.

These microglial cells are sentinels of the brain and react to any damage or infection. This reaction, in principle beneficial, becomes harmful when it is prolonged over time, causing chronic inflammation, aggravating the disease and promoting its progression.

This experimental development was carried out using animal models of this disease, whereby it was possible to discover that the drugs that activate this receptor improve the symptoms during the chronic phase of the disease by promoting tissue repair. nervous.

"We are witnessing a discovery that opens a new channel of pharmacological development for the treatment of the progressive phase of multiple sclerosis, and with it we want to open a new door to improving quality. of life for people with multiple sclerosis, "adds researcher Maria Domercq

Journal of Medicine.