Is this new combo of 3 drugs a fountain of youth?

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Is rejuvenation of the thymus a key to restoring youth? Maybe that's it.

A very surprising result & nbsp;appeared last week in a newspaper called & nbsp;Aging cell. A team of scientists published the first results of a study showing, in a small group of elderly men, that some signs of aging could be reversed with a combination of 3 drugs.

Not only slowed down. Reversed.

If it holds up, it could literally change the lives of millions of people. At first I was very skeptical after reading countless claims of anti-aging treatments over the years, which almost all proved wrong. Anti-aging treatments are a huge commercial market, full of misleading promises and vague claims. Restorative Skin Treatments for Youth (that do not work) are particularly popular with cosmetic companies. & nbsp;

But this new study is different. Scientists have decided to investigate whether recombinant human growth hormone (rhGH) could help restore the thymus. Your thymus is in the middle of the chest and is part of the immune system. It contributes to the production of T cells that fight infections. As you get older, the thymus contracts and begins to "clog with fat", at & nbsp;an article in & nbsp;Nature& nbsp; put it. The clues that rhGH could help restore the thymus go back decades, but they had never been tested before in humans.

The scientists responsible for the study added two other drugs, DHEA and metformin, because rhGH carries an increased risk of diabetes. Both drugs help prevent diabetes and & nbsp;both could also have anti-aging benefits, although none of them is known to affect the thymus.

Surprisingly, in 7 out of 9 men in the study (it was a very small study), the thymus showed obvious signs of reversal of aging, a new thymic tissue replacing fat. The side effects of rhGH are very mild and none of the men in this study had significant problems with either itself or the other two medications.

Another unexpected anti-aging sign was just as remarkable. The study measured "epigenetic age" in all subjects according to four different methods. "Epigenetic Age" refers to markers at the cellular level that change with age and & nbsp;the study explains:

"Although epigenetic age does not measure all the characteristics of aging and is not synonymous with aging, it is the most accurate measure of the risk of biological disease related to the age available. nowadays."

After 9 months of treatment, the epigenetic age of men in this study was & nbsp;2.5 years younger. The treatment does not only slow down the aging, it conversely. The effects persisted six months later: a year and a half after the start of the study, the epigenetic age of the man was 1.5 years younger than at the beginning. It's really remarkable. & Nbsp;

Any study has limits, so I have to mention a few here. First, the study was very small, only 9 men, but the effects were strong and significant. Second, the study's lead scientist, Gregory Fahy, is the co-founder of a company called & nbsp;Intervention immune& nbsp; plans to market anti-aging treatments. The authors also include scientists from Stanford, UCLA and the University of British Columbia.

A few years ago & nbsp;I wrote about another combination of drugs, dasatinib and quercetin, which have shown great promise to reverse the aging process, but only in mice. We are still waiting to learn more about this treatment, although a test in humans & nbsp;showed some promise earlier this year. & nbsp;

The new combination of 3 drugs is the most promising I have ever seen. The potential benefits are enormous: as the study points out, they include lower risks for at least 8 types of cancer, heart disease and stroke. Unlike many other anti-aging treatments, this one has real plausibility and the effects on the thymus can be measured almost immediately. Hope this one works; we will all be better if this happens.

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Is rejuvenation of the thymus a key to restoring youth? Maybe that's it.

A very surprising result appeared last week in a newspaper called Aging cell. A team of scientists published the first results of a study showing, in a small group of elderly men, that some signs of aging could be reversed with a combination of 3 drugs.

Not only slowed down. Reversed.

If it holds up, it could literally change the lives of millions of people. At first I was very skeptical after reading countless claims of anti-aging treatments over the years, which almost all proved wrong. Anti-aging treatments are a huge commercial market, full of misleading promises and vague claims. Cutaneous treatments that restore youth (which do not work) are particularly appreciated by cosmetic companies.

But this new study is different. Scientists have decided to investigate whether recombinant human growth hormone (rhGH) could help restore the thymus. Your thymus is in the middle of the chest and is part of the immune system. It contributes to the production of T cells that fight infections. As you get older, the thymus contracts and starts to "clog with fat" as a new Nature Put the. The clues that rhGH could help restore the thymus go back decades, but they had never been tested before in humans.

The scientists responsible for the study added two other drugs, DHEA and metformin, because rhGH carries an increased risk of diabetes. Both medications help prevent diabetes and may also have anti-aging benefits, although none of them have an effect on the thymus.

Surprisingly, in 7 out of 9 men in the study (it was a very small study), the thymus showed obvious signs of reversal of aging, a new thymic tissue replacing fat. The side effects of rhGH are very mild and none of the men in this study had significant problems with either itself or the other two medications.

Another unexpected anti-aging sign was just as remarkable. The study measured "epigenetic age" in all subjects according to four different methods. "Epigenetic age" refers to markers at the cellular level that change with age, and as the study explains:

"Although epigenetic age does not measure all the characteristics of aging and is not synonymous with aging, it is the most accurate measure of the risk of biological disease related to the age available. nowadays."

After 9 months of treatment, the epigenetic age of men in this study was 2.5 years younger. The treatment does not only slow down the aging, it conversely. The effects persisted six months later: a year and a half after the start of the study, the epigenetic age of the man was 1.5 years younger than at the beginning. It's really remarkable.

Any study has limits, so I have to mention a few here. First, the study was very small, only 9 men, but the effects were strong and significant. Second, the study's lead scientist, Gregory Fahy, is the co-founder of a company called Intervene Immune that plans to market anti-aging therapies. The authors also include scientists from Stanford, UCLA and the University of British Columbia.

A few years ago, I wrote about another drug combination, dasatinib and quercetin, which seemed very promising for reversing aging, but only in mice. We are still waiting for more information on this treatment, although a test in humans has shown promising results earlier this year.

The new combination of 3 drugs is the most promising I have ever seen. The potential benefits are enormous: as the study points out, they include lower risks for at least 8 types of cancer, heart disease and stroke. Unlike many other anti-aging treatments, this one has real plausibility and the effects on the thymus can be measured almost immediately. Hope this one works; we will all be better if this happens.