[ad_1]
Most people with inherited metabolic disorders are born with a defective gene that causes a critical enzyme deficiency.
In the absence of cure, many patients with conbad conbad metabolic disorders must follow a strict and demanding diet all their lives.
The study, published in the journal Communications Chemistry, revealed that some compounds found naturally in green tea and red wine may block the formation of toxic metabolites.
Researchers led by Ehud Gazit of Tel Aviv University (TAU) in Israel, examined two compounds: epigallocatechin gallate (EGCG) and tannic acid.
EGCG is found naturally in green tea, which has attracted attention within the medical community for its potential health benefits.
Tannic acid, found in red wine, is known to prevent the formation of toxic amyloid structures that cause neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.
"In the case of conbad conbad metabolic diseases, the body does not produce a vital metabolic enzyme," said Shira Shaham-Niv, PhD student at TAU.
"As a result, metabolites – substances that are, among other things, the building blocks of DNA and proteins – accumulate in the body, an uncontrolled buildup that is toxic and can cause serious blood disorders. development and mental disorders, "says Shaham-Niv. .
"Our new study once again demonstrates nature's ability to produce the best drug candidate to treat some of the worst human diseases," he said.
Collectively, this group of disorders is an important part of pediatric genetic diseases. Phenylketonuria Disease (PKU), which produces the aggregation of the phenylalanine metabolite, is a common innate metabolic disease.
Infants with PKU must follow a strict diet without phenylalanine for the rest of their lives. If they do not, they can face serious debilitating development problems.
"But it's an incredibly difficult task, since phenylalanine is found in most of the food we consume," said Shaham-Niv.
"The avoidance of certain substances is the only way to prevent the long-term debilitating effects of conbad conbad metabolic diseases. We hope that our new approach will facilitate the development of new drugs to treat these disorders," he said. -he declares.
The research focused on EGCG and tannic acid using test tubes and cell culture systems. Both substances were tested on three metabolites related to three metabolic inborn diseases: adenine, cumulative tyrosine and phenylalanine.
The results were promising. Both tannic acid and EGCG are effective at blocking the formation of toxic amyloid structures. The researchers also used computer simulations to check the mechanism that drives the compounds.
"We are entering a new era of understanding the role and importance of metabolites in various diseases, including metabolic diseases, neurodegenerative diseases and even cancer," said Shaham-Niv.
"The tools we have developed are innovative and have enormous potential to help a wide range of patients in the future," he said.
Source link
