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Drinking green tea and red wine has been badociated with many health benefits, from a reduced risk of heart attacks and high blood pressure to potential protection against certain cancers. Now, a study suggests that compounds in these drinks can help block the formation of toxic molecules that cause severe developmental disorders and mental disorders.
The study, published in the journal Communications Chemistry, found that some compounds found naturally in green tea and red wine can block the formation of toxic metabolites and even help treat some conbad conbad metabolic diseases. Most people with inherited metabolic disorders are born with a defective gene that causes a critical enzyme deficiency. In the absence of cure, many patients with conbad conbad metabolic disorders must follow a strict and demanding diet all their lives.
Previous studies have shown that green tea can delay the deterioration caused by Alzheimer's disease and Parkinson's disease. Green tea can protect your brain in old age, thus reducing your risk of Alzheimer's and Parkinson's. Not only can green tea improve brain function in the short term, but it can also protect your brain during old age.
"The bioactive compounds of green tea can have various protective effects on neurons and can reduce the risk of Alzheimer's and Parkinson's, the two most common neurodegenerative diseases," said Dr. Anuj Kumar, a neurosurgeon based in Delhi
. Tannic acid, present in red wine, is known to prevent the formation of toxic amyloid structures that cause neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. (Shutterstock)
Investigators led by Ehud Gazit of Tel Aviv University (TAU) in Israel, examined two compounds: epigallocatechin gallate (EGCG) and tannic acid. EGCG is found naturally in green tea, which has attracted attention within the medical community for its potential health benefits. Tannic acid, found in red wine, is known to prevent the formation of toxic amyloid structures that cause neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.
"In the case of conbad conbad diseases, the body does not produce a vital metabolism. enzyme, "said Shira Shaham-Niv, PhD student at TAU.
"As a result, metabolites – substances that are, among other things, the building blocks of DNA and proteins – accumulate in the body.This uncontrolled accumulation is toxic and can cause severe developmental disorders and mental disorders, "said Shaham-Niv.
"Our new study demonstrates once again nature's ability to produce the best drugs." He said.
Collectively, this group of disorders is an important part of pediatric genetic diseases. Phenylketonuria Disease (PKU), which produces the aggregation of the phenylalanine metabolite, is a common innate metabolic disease. Infants with PKU should follow a strict diet without phenylalanine for the rest of their lives. If they do not, they can face serious debilitating development problems.
Most people with inherited metabolic disorders are born with a defective gene that causes a critical enzyme deficiency. (Shutterstock)
"But it's an incredibly difficult task, since phenylalanine is found in most of the food we consume," said Shaham-Niv.
"The avoidance of certain substances is the only way to prevent the long-term debilitating effects of conbad conbad metabolic diseases, and we hope that our new approach will facilitate the development of new drugs to treat these disorders," he said. he said.
The research focused on EGCG and tannic acid using test tubes and cell culture systems. Both substances were tested on three metabolites related to three metabolic inborn diseases: adenine, cumulative tyrosine and phenylalanine.
The results were promising. Both tannic acid and EGCG are effective at blocking the formation of toxic amyloid structures. The researchers also used computer simulations to check the mechanism that drives the compounds.
"We are entering a new era of understanding the role and importance of metabolites in a variety of diseases, including metabolic, neurodegenerative and even cancer diseases. Niv said.
"The tools we have developed are revolutionary and have enormous potential to help a wide range of patients in the future," he said.
(With the contributions Press Trust of India)
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