Israeli study finds Covid vaccine much safer than catching virus

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This is the first large study to compare the risks of vaccination versus infection face to face in the same population during the same time period, and it shows that the risks of infection far outweigh the risks of the vaccine, the researchers said.

“In this study in a nationwide mass vaccination setting, the BNT162b2 vaccine was not associated with a high risk of most of the adverse events examined,” wrote Dr. Ran Balicer of the Research Institute. Clalit in Tel Aviv and colleagues in their report, published in the New England Journal of Medicine.

They found additional cases of myocarditis – a type of heart inflammation that has been linked to two mRNA vaccines, made by Moderna and Pfizer. It has added up to about three additional cases per 100,000 people vaccinated and has been seen almost entirely in young men.

“The main potential adverse events identified included an excessive risk of lymphadenopathy (swelling of the lymph nodes), herpes zoster infection (shingles), appendicitis and myocarditis,” they wrote.

“To put these risks into context, we also looked at data from more than 240,000 infected people to estimate the effects of a documented SARS CoV-2 infection on the incidence of the same adverse events,” they said. added.

“Infection with SARS-CoV-2 was not estimated to have a significant effect on the incidence of lymphadenopathy, shingles infection or appendicitis, but it was estimated to pose a risk. substantial excess myocarditis. “

Covid-19 infection increased myocarditis risk far more than vaccination – around 11 cases per 100,000 people vaccinated, they found.

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They also found some surprises.

“Some initially unexpected effects were observed in the results of the present study. The BNT162b2 vaccine appears to protect against certain conditions such as anemia and intracranial hemorrhage,” they wrote. “These same adverse events are also identified in this study as complications of SARS-CoV-2 infection, so it seems likely that the protective effect of the vaccine is mediated by its protection against SARS-CoV infection. -2 undiagnosed, ”they added.

Dr Grace Lee, a pediatrician at Stanford University who chairs the U.S. Centers for Disease Control and Prevention’s advisory committee on immunization practices, said the results provide valuable information.

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“Messenger RNA (mRNA) vaccines may be associated with myocarditis, but they may also prevent cases of myocarditis, acute renal failure, arrhythmia, and thromboembolic disease,” wrote Lee, who did not participated in the study, in a commentary.

“The key to comparing these risks depends on the risk of infection with SARS-CoV-2 to an individual person, and that risk may vary by location and over time. Given the current state of the global pandemic, however, the risk of exposure to SARS-CoV-2 seems inevitable. “

Last June, the United States Food and Drug Administration added a warning about the risk of myocarditis and a related inflammatory condition called pericarditis to the Covid-19 mRNA vaccine fact sheets.

Doctors say it’s important to diagnose the condition early, but it’s easy to treat and patients recover without too much trouble.

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