Diabetes Risk Associated with Cirrhosis, Not Chronic HCV Infection, in HIV-Positive Patients

July 2, 2018

Cirrhosis is badociated with an increased risk of diabetes mellitus in patients living with HIV.

In HIV-infected patients, cirrhosis but not chronic infection with hepatitis C virus (HCV) is badociated with an increased risk of diabetes mellitus, according to a multicenter study published in Alimentary Pharmacology & Therapeutics

French researchers prospectively followed 28,699 patients living with HIV for an average duration of 12.4 ± 7.9 years. Among these patients, 969 (3.4%) developed diabetes over an average period of 11.0 ± 6.4 years, giving a DM rate of 2.74 cases per 1000 person-years of follow-up.

Four thousand and four patients were co-infected with chronic HCV infection, and among these patients, 164 (4.1%) developed diabetes, which was a significantly higher rate than monoinfected patients with HIV. (4.1% vs. 3.2%, P <007). Old age, high body mbad index, AIDS status, a number of CD4 nadir cells ≤200 / mm ³ a detectable HIV viral load and cirrhosis are badociated with the development of DM, but HCV and chronic hepatitis B

Although a history of interferon-based anti-HCV treatment has not been badociated with DM development, a longer duration Antiretroviral combination therapy was badociated with a lower risk of DM

. "In conclusion, our study shows that in [patients living with HIV] cirrhosis is badociated with an increased risk of diabetes mellitus, but the prolonged virologic response does not appear to be related to the development of diabetes.", States the authors