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Excessive bleeding commonly known as postpartum hemorrhage (PPH) after badl birth is the leading cause of these deaths.
PIC: Stable-Heat Carbetocin is the new drug that could save thousands of women from work. According to Resaerch, the drug helps control excessive bleeding in mothers.
HEALTH
KAMPALA – In low and middle income countries; where Uganda falls, thousands of women die each year due to complications related to maternal and child birth.
Excessive bleeding, commonly known as postpartum haemorrhage (PPH) after badl birth, is the leading cause of these deaths
. a clinical trial, the largest of its kind, has studied nearly 30,000 women with initial births, commonly known as normal births in 10 countries, new evidence that thermostable carbetocin is as effective as oxytocin.
of care in the prevention of excessive bleeding after badl delivery recommended by the World Health Organization (WHO).
The results of this new drug have recently been published in the New England Journal of Medicine.
Ten countries that participated in the study understand; Argentina, Egypt, India, Kenya, Nigeria, Singapore, South Africa, Thailand, United Kingdom and Uganda where more than 3,185 women were recruited in Uganda.
Each woman randomly received a single injection of thermostable carbetocin or oxytocin. Immediately after the birth of his baby
The study found that both drugs were also effective in preventing excessive bleeding after birth.
Prof. Josaphat K. Byamugisha, co-principal investigator of the study in Uganda explains that the new drug integrates well in the country's humid and hot temperatures unlike oxytocin which has limitations in terms of storage and transport. According to the results of the study, oxytocin should be stored and transported between 2 and 8 degrees Celsius, but studies in low- and middle-income countries reveal a deterioration and loss of efficacy Oxytocin ampoules, therefore, thermostable carbetocin retains its effectiveness for at least three years at 30 degrees Celsius and six months. at 40 degrees Celsius.
"Although in action the two drugs are the same, stable heat carbetocin does not require refrigeration, it remains stable and effective for a longer period."
"This drug will suit our environment with higher and wetter temperatures" In most of our health facilities, oxytocin was stored at the surface due to lack of refrigerators, which reduced its effectiveness [19659015] He added:
Statistics
Worldwide, 14 million women are affected each year by the PPH, which is the leader. Uganda has experienced a dramatic decline in maternal mortality rates from 438 deaths per 100,000 live births recorded in Uganda's 2011 health survey to 336 current deaths. these deaths must be further reduced.
"This is an important step in the prevention of PPH and these findings pave the way for thermostable carbetocin that could potentially save the lives of thousands of fe even in areas where the transport and storage of the cold chain are not feasible, "said Professor Klaus Dugi, Chief Medical Officer, Ferring Pharmaceuticals.
Add: "We will now work with the WHO and MSD carbetocin available in the countries where it is most needed, protecting women and families around the world.
Olive Sentumbwe- Mugisa, Family and Population Health Advisor, WHO, said that stakeholders will first make decisions on how best to implement the use of the drug before its introduction. on the Ugandan Market.
Study
This WHO study, also called CHAMPION trial (Carbetocin Haemorrhage Preventoin), was funded by MSD for Mothers.
Thermostable Carbetocin was provided by Ferring Pharmaceuticals, the product innovator and oxytocin was
The study was conducted as part of a collaborative agreement between the WHO, MSD for Mothers and Ferring Pharmaceuticals
to the positive results of the trial, the parties will now work to advance affordable access to this study. drug that saves lives in countries that have a heavy burden of maternal mortality.
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