Analysis of 6000 mutations of the HIV protein … Development of the AIDS vaccine

Entry on 2019.06.09 16:07

Korean researchers have opened the possibility of developing antibodies for the treatment of Acquired Immunodeficiency Syndrome (AIDS). By badyzing all the mutations of the human immunodeficiency virus (HIV) at the origin of AIDS, it is possible to design a representative viral protein and develop a therapeutic vaccine through the production of directed antibodies. against this one.

The Korean Research Foundation (KFRI) announced on July 9 that Han Byung-woo, a professor at the College of Pharmacy of the Seoul National University, had suggested the possibility of inducing therapeutic antibodies by designing a representative structure of the proteins of the immunodeficiency virus.

The team badyzed all mutations of the human immunodeficiency virus and then modified ConM, a protein designed to best represent the entire coat protein, to optimize vaccine development.

The human immunodeficiency virus (HIV) is so diverse that it has tried to overcome the problem of making the right drug. To do this, the team badyzed all the sequences of more than 6,000 envelope proteins of human immunodeficiency virus and identified three-dimensional structures of proteins that can be used universally.

The research team conducted an experiment on animals to determine if the protein cone was designed to induce antibodies. When condoms were given to rabbits and caterpillars, the antibodies appeared to be able to respond to the human immunodeficiency virus present in the body of each animal.

In particular, this antibody has the effect of largely neutralizing various mutant proteins of the human immunodeficiency virus. By using a protein design method such as that of KM, it should be possible to develop therapeutic agents capable of managing mutated proteins such as the influenza virus and the Ebola virus.

Professor Han Byeong-woo said: "The results of this study can be directly applied to the study of human immunodeficiency virus vaccine, difficult to develop for treatment." Applying this principle in the future, it is possible to develop the influenza virus, We will also study viral proteins. "

The results of the study were published in the May 30 issue of Nature Communications.