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Dr. Kim Jin-soo, a researcher at the Korea Atomic Energy Research Institute, said she injected trastuzumab, a targeted anti-cancer treatment for cancer cells, and atorvastatin, a treatment of hyperlipemia, then a positron emission tomography (PET / CT). Magnetic resonance imaging (MRI) showed a decrease in glucose metabolism and glucose volume in the frontal lobe of the brain with simultaneous administration of trastuzumab alone, trastuzumab and atorvastatin at the same time. Said Thursday. In fact, when the mice were treated with trastuzumab and atorvastatin at the same time, they remained at normal levels, and cerebral cytotoxin badysis showed that during the administration of trastuzumab, the cytokines induced by inflammation were multiplied by 4. At the same time, stujudicate and atorvastatin regained normal levels.
The team also found that atorvastatin penetrated deep into the tumor and increased tumor absorption, thereby reducing the tumor size by 36% compared with the single administration of the tumor. trastuzumab.
The results of the study were published online in the Feb. 11 issue of the Journal of Clinical Medicine, International Famous Cancer Journal.
The authors of this article are: (1) The effects of chemobrain induced by trastuzumab, chemobrain rescue of atorvastatin with enhanced anticancer effect and without the side effect of hair loss. (Co-author, Korean Institute of Nuclear Engineering) and Kim Jung-min (Korea University).
Dr. Jin-Soo Kim said: "We hope that the current state of insoluble cancer treatment will be improved by increasing the possibility of clinical trials of antibody therapy using radiopharmaceuticals labeled with alpha particles,
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