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IBS Kim Gwang-myeong, director, "Expect to use RNA gene therapy technology"
There is a mixed tail structure in which several types of bases are connected at the end of "messenger RNA" (mRNA), which transmits the genetic information contained in the DNA in proteins, to Korean researchers,
A team of researchers from the RNA Research Center of the Institute of Basic Sciences (IBS), Kim Gwang-moi, a professor in the Department of Biosciences of the 39; Seoul National University, A) and guanine (G), and discovered the function of the "mixed tail" to provide a framework for a new understanding of the life of messenger RNA and gene regulation.
The results of this research by Kim Jang-jin (corresponding author) and Lim Jae-chul, Kim Dong-wan and Lee Young-seok (first joint author) were published in the international journal Science.
Messenger RNA is a mediator that transfers genetic information from DNA to proteins and is a key ingredient in all activities of life. The messenger RNA has been known to protect the function of messenger RNA and promote protein synthesis by forming a "long tail of adenine" (poly tail [A]) that only the basics Adenine are bound during maturation.
However, Kim first reported to academics that there was a "mixed tail" with adenine and guanine added to the adenine tail position in 2014, and the role of the process.
The researchers found that these mixed tails contributed to the activation of these genes by protecting them from the degradation of messenger RNA.
They found that a tail sequencing method, a large-capacity, self-developed basic baday method, was used to add a base other than adenine to the end of the messenger RNA, resulting in the formation of a mixed tail
TENT4A and TENT4B This mixed tail was found to be more resistant to degradation than the long tail of adenine, composed only of adenine, protecting the messenger RNA and increasing the life of the RNA.
In fact, the experimental elimination of enzymes TENT4A and TENT4B showed that these cells promoted the degradation of messenger RNA.
"This study refutes the existing theory that the tail of messenger RNA consists solely of adenine, and identifies the process and function of the mixed tail," the researchers said. "The RNA protection mechanism of the mixed tail is an RNA and can be used to improve the effectiveness of the treatment."
Kim said, "We first discovered the mixed tail function of RNA in this study." It is important to note that the tail of RNA can be used for gene regulation, I can do it. "
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