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January 24, 2019 12:00
Professor, Kang Kang – yeol. Department of Biotechnology, Yonsei University
Korean researchers have proposed a new strategy for treating liver cancer by directly controlling the proteins that cause cancer.
The Korean Research Foundation announced yesterday that a research team led by Professor Choi Kang-yeol of Yonsei University had discovered a protein that inhibited cancer by digesting a typical cancer-causing protein, Ras, and published the results of his research in the international journal Nature Communications. .
It is likely that the las protein happens to be a mutation in most cancers. Mutations of Ras cause cancer by activating signal transduction systems badociated with cell growth. Due to resistance to a large number of targeted anti-cancer drugs, it has been difficult to develop anti-cancer drugs that control ras protein.
Professor Choi's research team, Kang-Yeol, has discovered a new protein that binds to Lars protein using normal tissues and liver cancer tissues from patients with high blood pressure. liver cancer Among the proteins discovered by the researchers, we discovered that a protein called "WDR76" degrades the Lars protein efficiently.
The researchers also used the WDR76 protein to control the stability of the las protein and the control of liver cancer. Experiments comparing mice with liver cancer and normal mice have shown that when the WDR76 protein is deficient, the Ras protein is lengthened and that a liver cancer develops. Conversely, when the WDR76 protein was overexpressed, the Ras protein was degraded and the liver cancer was removed.
Professor Choi Kang-yeol said, "Although we have tried to identify and modify the structure of the Ras protein mutation up to now, this study has suggested a new paradigm for controlling the protein. Protein activity by controlling the amount of Ras protein is expected to contribute to the development of an effective cancer treatment agent. "
The research was carried out with the support of the Ministry of Science and Technology, the Ministry of Information and Communication and the Basic Research Project of the Korea Research Foundation (first research center). plan).
University of Yonsei Department of Biotechnology
January 24, 2019 12:00
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