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A new study suggests that there is hope that aspirin – one of the most widely used drugs in the world – can help treat some aspects of the disease. Devastating Alzheimer's.
Scientists have discovered that aspirin works with a specific non-atomic mechanism in the brain that prevents amyloid plaques and sticky protein drops around brain cells, which would be the leading cause of the disease. 39, Alzheimer's, according to a recent study. On the mice.
Experiments in mice in the study revealed that aspirin stimulates the ability of lysosomes (which are somewhat similar to cells that treat and recycle cell debris) to eliminate amyloid plaques or to to prevent them from forming. "Aspirin should have the same effect on Alzheimer's disease as it does on humans," said the researchers, who published their findings on July 2 in the journal Neuroscience.
Alzheimer's disease is the most common form of dementia, an ascending cerebral disease that affects nearly six million Americans, the sixth leading cause of death among all adults in the United States, according to the Centers for Disease Control and Prevention.
There is no cure, and the drugs have also achieved very limited success in slowing the progression of the disease.
Aspirin, also known as acetylsalicylic acid, is a reasonably priced drug that has been used safely in low doses for a century, regardless of gastric irritation possible and at low risk of intestinal bleeding.
Many adults take a small dose of aspirin each day as a mild blood solvent to prevent heart attacks.
In fact, in a large-scale study on aspirin and heart health, aspirin has also been found to reduce the risk of Alzheimer's disease even moderately.
Chinese researchers published a meta-badysis META (badysis of a research result by incorporating the results of a number of independent research) last March in the journal Frontiers in Aging neuroscience by examining 18 studies at the population level. (NSAIDs), including aspirin, is badociated with a lower risk of developing Alzheimer's disease averaging 20%.
Based on the possible relationship between aspirin and the prevention of Alzheimer's disease – observed for the first time in ten years or more – Laboratory. "Both approaches – both in the body and in the laboratory – seem to prevent or reverse the biological signs of Alzheimer's disease," says Calibada Bahan, author of the main study and professor of neuroscience at the University of California. Rush University.
Bahan explains: "Aspirin activates a cellular future called PPARα, which in turn regulates the protein (TFEB – the main regulator of lysosomal activity)."
In short, aspirin helps cells clear cellular debris, which includes proteins forming amyloid plaques.
Bahan added to the magazine: Live Science "We expect to see the same results in the cells of the human brain."
In fact, other drugs such as gemfibrozil, which lowers triglycerides in the blood (also known as Lopid), control other TFEB proteins, but aspirin is sufficiently safe to be available without a prescription and has fewer side effects. "The recent study offers a great mechanical explanation for the protective effects of aspirin at the cellular level and animal models," said Rajini Rao, a professor of physiology at Johns Hopkins University in Baltimore who does not have a doctor. was not involved in the research.
However, she noted that the study did not determine whether the degree of improvement in the amyloid removal would result in better brain function.
The results of epidemiological studies on the use of aspirin for dementia are very different, Rowe told Live Science magazine. While there are indications of protection, some studies do not. fail to confirm it.
Unfortunately, this is the case with all the drugs used in Alzheimer's disease trials and over 99% of them have failed, which is why research on Alzheimer's disease and more than 99% of them have failed, which is why research on the Alzheimer's disease is a particular challenge. "Although aspirin is relatively safe, it is at risk when it is used every day, and should not be used as an unsupported way to treat or prevent the disease." Alzheimer's, "said Bahan.L 'aspirin can also stimulate Lizosome activity.
PPARÎ ± receptors must exist, so that aspirin does not affect any patient with insufficient PPARÎ ± receptors, which explains the conflicting results of the study at the population level. (19659024)
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