Media advisory

Monday 25 January 2021

What

Unlike previous findings, treatment with low-dose aspirin before conception and early in pregnancy may increase the chances of pregnancy and live births in women who have had a previous miscarriage or two, suggests a study by researchers from the National Institutes of Health. Rather than just looking at the difference in pregnancy rates between women who received aspirin and those who received a placebo, the study also took into account the differences in total aspirin use between the women. who deviated from the daily regimen and those who adhered to it.

The research team was led by Enrique Schisterman, Ph.D., of the Epidemiology Branch of the NIH. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and colleagues. It appears in the Annals of Internal Medicine.

Published in 2014, Aspirin’s Effects on Pregnancy and Reproduction (EAGeR) trial included more than 1,000 women between the ages of 18 and 40 with one or two previous miscarriages. The women were given low-dose aspirin (81 milligrams) or a placebo daily while trying to conceive. If they conceive, they would continue to receive this diet for the 36e week of pregnancy. Although the study found no overall difference in miscarriage rates between the two groups, there was a higher birth rate for the subgroup of women who had only suffered one miscarriage. before the 20th week of pregnancy.

Unlike the original analysis, the current reanalysis looked at whether a participant adhered to treatment or skipped days or discontinued it altogether due to side effects such as bleeding, nausea, or vomiting. Compared to the placebo group, per 100 women, adherence to the aspirin regimen for five to seven days per week led to eight additional positive pregnancy tests, six fewer pregnancy losses, and resulted in another 15 live births. . Women who adhered to therapy four days a week had similar results. The researchers concluded that taking low-dose aspirin at least four days a week could improve the chances of pregnancy and live birth in this group of women.

who

Lindsey Sjaarda, Ph.D., scientist in the Epidemiology Branch of NICHD, is available for comment.

h3> Article

Naimi, AI et al. The effect of low-dose aspirin initiated before conception on pregnancy detected by human chorionic gonadotropin, pregnancy loss and live birth: protocol analysis of a randomized trial. Annals of Internal Medicine. 2021.

About Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): NICHD leads research and training to understand human development, improve reproductive health, improve the lives of children and adolescents, and optimize capacity for all. For more information, visit https://www.nichd.nih.gov.

About the National Institutes of Health (NIH):NIH, the nation’s medical research agency, comprises 27 institutes and centers and is a component of the US Department of Health and Human Services. The NIH is the principal federal agency that conducts and supports basic, clinical and translational medical research, and studies the causes, treatments, and cures for common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

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