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London, Jul 15 (PTI) Herpesvirus may increase the likelihood of developing Alzheimer's disease, according to a study that also found that antiviral drugs can significantly reduce the risk of neurodegenerative disorder .
In a research published in last February, Taiwanese epidemiologists examined subjects who suffered from severe herpes infection and aggressively treated with antiviral drugs
Scientists from the University of Manchester and the University of Edinburgh in the UK state that the study shows Type 1 (HSV1) leads to an increased risk of developing the disease.
It also supports the viability of a potential way to reduce the risk of Alzheimer's disease.
"This article and two more by different research groups in Taiwan provide the first population evidence for a causal link between infection with the herpes virus and Alzheimer's disease , an extremely important finding, "said Ruth It Zhaki, a professor at the University of Manchester in the UK.
The new findings, published in the Journal of Alzheimer Disease, argues that the previous study provides the strongest evidence yet for a causal link between herpes and Alzheimer's disease. 19659002] "I believe that we are the first to realize the implications of this striking data for this devastating disease that mainly affects the elderly." "There are almost 30 million people in the world who suffer from it and unfortunately this figure will increase. as longevity increases, "he said,
" But we think these methods are safe and easy to use, and the available antivirals can play an important role in the fight against the disease in these patients. It also raises the future possibility of preventing the disease by vaccinating against the virus in childhood, "he said.
Most Alzheimer's researchers are studying its key features – amyloid plaques and neurofibrillary tangles: the causes of their formation are unknown
HSV1 infects most humans in youth or later and remains repetitive in the body in dormant form in the peripheral nervous system.
From time to time the virus becomes activated and in some people it causes a visible lesion in the form of herpes labialis.
The Taiwan study identified 8,362 subjects aged 50 years or older between January and December 2000, who had recently been diagnosed with severe HSV infection
. group of 25,086 people with no evidence of HSV infection.
The researchers then monitored the development of dementia in these people over a 10-year follow-up period. ars between 2001 and 2010.
The risk of developing dementia in the HSV group was multiplied by 2.542. However, when the researchers compared those in the HSV cohort who were treated with antiviral treatment versus those who did not receive it, there was a ten-fold reduction in the late incidence of the dementia over 10 years
. the remarkable antiviral effect, but also the fact that – despite the relatively short duration and timing of treatment – in most patients severely affected by HSV1, it seems to prevent long-term damage in the brain that causes the disease of Alzheimer's, "said Richard Lathe. from the University of Edinburgh. PTI MHN MHN
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This is an unedited, unformatted feed from the Press Trust of India thread
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