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On Monday, November 5, four TURBO grants were awarded for new medico-technical research proposals. The grants are part of the TURBO program, a collaboration between the University of Twente and the Radboudumc . Research groups from both institutions can use the grant to develop an innovative idea that should lead to a complementary question with an external grant provider. It's the second year that the TURBO program is running.
The TURBO program started in 2017 and stands for "Twente University RadBoudumc Opportunities". He enrolled in the TopFit program which concretizes the "Concepts for a healthy life" innovation profile of the East Netherlands region. A TURBO grant is intended to prepare a project for the acquisition of larger external grants, such as national and European funds and companies in the health and technology sector. In the TechMed magazine of June 2018, two scientists talk about one of last year's winning studies: the simulation of the blood-brain barrier for the development of personalized medicines.
Studies
Tumor-on-a-chip
The hypoxia (oxygen deficiency) of a tumor reinforces its aggressiveness and harms the effectiveness of the tumor. immunotherapy. There is currently no treatment that specifically targets hypoxic cells in tumors. The researchers Severine the Gac (UT) and Roland Brock (Radboudumc) will develop an intelligent tumor on a chip that can mimic these complex tumor structures, to study possible ways to specifically kill these cells hypoxic cancer.
Prof. Dr. Jai Prakash
A 3D brain tumor environment
It is not yet possible to reproduce brain structure in 3D with organ-on-chip technology. As a result, the knowledge of the interaction between gliomas (a type of tumor) and the surrounding cells in the brain is only rudimentary. The researchers Peter Friedl (Radboudumc) and Jai Prakash (UT) wish to develop a tumor microenvironment in 3D allowing the brain to explore this interaction and to see how it works. thus orientate towards targeted treatments. 19659011] Prof.dr.ir. H.J. Hermens
Measuring Resilience Using Portable Sensors
Often, people who break their hip do not recover optimally. This leads to increased disease burden for the patient and costs to society. Treatment outcomes will be better if physicians can better predict and quantify the individual resilience of patients. The researchers René Melis (Radboudumc) and Hermie Hermens (UT) will develop a system based on portable sensors and intelligent algorithms, with which this resilience can be measured and which can support treatment decisions. 19659014] Prof. Dr. Baziel van Engelen
